Results 21 to 30 of about 11,155,248 (357)

Mapping of a N-terminal α-helix domain required for human PINK1 stabilization, Serine228 autophosphorylation and activation in cells

Open Biology, 2022
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways.
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit   +14 more
doaj   +1 more source

PKCɛ switches Aurora B specificity to exit the abscission checkpoint

Nature Communications, 2016
The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit ...
Tanya Pike, Nicola Brownlow, Svend Kjaer, Jeremy Carlton, Peter J. Parker   +4 more
doaj   +1 more source

Erythrocyte Protein Phosphorylation

Journal of Biological Chemistry, 1973
Abstract Human erythrocyte membrane protein components have been phosphorylated by an endogenous protein kinase. This transfer of phosphate from [γ-32P]ATP was stimulated by cyclic adenosine 3',5'-monophosphate and inhibited by calcium. The formation of phosphoserine and phosphothreonine bonds and the negligible effect of large changes in sodium and ...
A D, Roses, S H, Appel
openaire   +2 more sources

The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

International Journal of Molecular Medicine, 2017
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases.
F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. Muzio   +4 more
semanticscholar   +1 more source

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis [PDF]

, 2005
Several kinases phosphorylate vimentin, the most common intermediate filament protein, in mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the cleavage furrow-specific vimentin phosphorylation.
Erich A. Nigg, Andreas Uldschmid, Hanisch, Anja, Uldschmid, Andreas, Takashi Oguri, Takai, Yasushi, Tomoya Yamaguchi, Yasushi Takai, Masaki Inagaki, Goto, Hidemasa, Tomoya Yokoyama, Anja Hanisch, Hidemasa Goto, Silljé, Herman, Herman Silljé, Oguri, Takashi, Yamaguchi, Tomoya, Nigg, Erich A., Inagaki, Masaki, Yokoyama, Tomoya   +19 more
core   +1 more source

Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor

Lupus Science and Medicine, 2021
Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen, Tsvetana Petrova, Sambit K Nanda, Cheryl Scudamore, Stephen W Wright, Vikram R Rao   +5 more
doaj   +1 more source

DeepPhos: prediction of protein phosphorylation sites with deep learning

Bioinform., 2019
Motivation Phosphorylation is the most studied post-translational modification, which is crucial for multiple biological processes. Recently, many efforts have been taken to develop computational predictors for phosphorylation site prediction, but most ...
Fenglin Luo, Minghui Wang, Yu Liu, Xinghe Zhao, Ao Li   +4 more
semanticscholar   +1 more source

An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins

Bio-Protocol, 2017
We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) (Fulcher et al., 2016 and 2017).
Thomas Macartney, Gopal Sapkota, Luke Fulcher   +2 more
doaj   +1 more source

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

eLife, 2022
The p97/Cdc48 ATPase and its ubiquitin receptors Ufd1-Npl4 are essential to unfold ubiquitylated proteins in many areas of eukaryotic cell biology.
Ryo Fujisawa, Cristian Polo Rivera, Karim PM Labib   +2 more
doaj   +1 more source

Adenylate effects on protein phosphorylation in the interenvelope lumen of pea chloroplasts [PDF]

, 1989
A 64-kilodalton (kDa) protein, situated in the lumen between the inner and outer envelopes of pea (Pisum sativum L.) chloroplasts (Soll and Bennett 1988, Eur. J.
Soll, Jürgen, Berger, Veronika, Bennett, John   +2 more
core   +1 more source