Results 91 to 100 of about 3,948,731 (294)

Differential Display of Protein Tyrosine Kinase cDNAs from Human Fetal and Adult Brains

BioTechniques, 2002
Here we describe a differential display method for surveying the expression of most protein tyrosine kinases and applying it to cDNAs from human fetal and adult brains. The method involves two selective steps for processing the mRNA.
M. Okada, S. Yamaga, S. Yasuda, S.M. Weissman, Y. Yasukochi   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Novel approaches to targeting protein tyrosine kinases

, 2015
Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal cellular functions such as growth, cell cycle control, proliferation, differentiation, migration, cellular survival and apoptotic induction.
McCullough, D., Trim, C.
core  

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
Christoph S Clemen, Linh Hai Vu (527338), Clemen, Christoph S., Na, Jianbo, Christoph S. Clemen (130148), Araki, Tsuyoshi, Linh Hai Vu, Na Jianbo, Araki Tsuyoshi, Tsuyoshi Araki (506033), Williams Jeffrey G., Eichinger Ludwig, Vu Linh Hai, Eichinger, Ludwig, Jeffrey G Williams, Williams, Jeffrey G., Jianbo Na, Ludwig Eichinger, Tsuyoshi Araki, Jianbo Na (12352), Clemen Christoph S., Vu, Linh Hai, Jeffrey G. Williams (335697), Ludwig Eichinger (11966)   +23 more
core   +1 more source

Receptor Protein Tyrosine Kinases and Phosphatases

Cold Spring Harbor Symposia on Quantitative Biology, 1992
It is clear that the number of receptor PTKs and PTPs encoded by a typical vertebrate genome is rather large. Although the signal pathways activated by the receptor PTKs may in many cases be common, specificity is provided by the ligand-binding domain and the availability of ligand.
T, Hunter, R A, Lindberg, D S, Middlemas, S, Tracy, P, van der Geer   +4 more
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]

, 2008
Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core   +1 more source

Alternative Splicing in Oncogenic Kinases: From Physiological Functions to Cancer

Journal of Nucleic Acids, 2012
Among the 518 protein kinases encoded by the human kinome, several of them act as oncoproteins in human cancers. Like other eukaryotic genes, oncogenes encoding protein kinases are frequently subjected to alternative splicing in coding as well as ...
Sabine Druillennec, Coralie Dorard, Alain Eychène   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Role of Protein Kinases in Antigen-activation of Peripheral Blood Mononuclear Cells of Schistosoma mansoni Infected Individuals

Memorias do Instituto Oswaldo Cruz, 1997
T cell recognition of antigens displayed on the surface of antigen presenting cell results in rapid activation of protein tyrosine kinases and kinase C.
Almeida Célia A, Goes Alfredo M
doaj