Results 231 to 240 of about 184,784 (335)

Progress in research on osteoporosis secondary to SARS‐CoV‐2 infection

Animal Models and Experimental Medicine, EarlyView.
This review explores the potential mechanisms, complications, risk factors, and future research directions related to osteoporosis secondary to SARS‐CoV‐2 infection. Key mechanisms include an imbalance between osteoclast and osteoblast activity driven by direct viral effects on bone, inflammation, hypoxia, dysregulation of noncoding RNAs, and metabolic
Jinlong Wang, Yibai Xiong, Zhiqi Song, Yanhong Li, Ling Zhang, Chuan Qin   +5 more
wiley   +1 more source

Target Agnostic Photoaffinity Labelling by Sulfonylhydrazones

Angewandte Chemie, EarlyView.
Sulfonyl hydrazones were identified as new photo‐crosslinkers exploiting their base catalyzed low‐energy photoactivation that leads to reactive carbenes. The amino acid promiscuity, their usefulness in proteomics application and the range of labelled targets including enzymes, a PPI target and a transcription factor suggests that sulfonyl hydrazones ...
Kristóf Garami, Nikolett Péczka, László Petri, Tímea Imre, Tamás Langó, Zoltán Szabó, Zoltán Orgován, Pál Szabó, György Miklós Keserü, Péter Ábrányi‐Balogh   +9 more
wiley   +2 more sources

The Ever-Expanding Influence of the Endothelial Nitric Oxide Synthase. [PDF]

Basic Clin Pharmacol Toxicol
Rafea R, Siragusa M, Fleming I.
europepmc   +1 more source

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

, 1991
James E. Ferrell, M. Wu, J C Gerhart, Greg S. Martin   +3 more
openalex   +1 more source

Sugar‐sensing swodkoreceptors and swodkocrine signaling

Animal Models and Experimental Medicine, EarlyView.
Sugar‐sensing swodkoreceptors that trigger swodkocrine signaling. Abstract Sugars are one of the major metabolites and are essential for nucleic acid synthesis and energy production. In addition, sugars can act as signaling molecules. To study sugar signaling at the systemic level, there is an urgent need to systematically identify sugar‐sensing ...
Savani Anbalagan
wiley   +1 more source

Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4

Angewandte Chemie, EarlyView.
The transcription factor STAT4 is a therapeutic target for autoimmune diseases. Here, para‐biaryl phosphates and phosphonates are presented as the first small‐molecule inhibitors of STAT4. The phosphonate Stafori‐1 selectively stabilizes STAT4 against thermal denaturation in cell lysates, and its cell‐permeable prodrug Pomstafori‐1 selectively inhibits
Nadiya Brovchenko, Angela Berg, Sabine Schubert, Julian Gräb, Theresa Münzel, Christoph Protzel, Kalaiselvi Natarajan, Thorsten Berg   +7 more
wiley   +2 more sources

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI. [PDF]

Cancer Cell Int
Chaudhary N, Choudhary BS, Shivashankar A, Manna S, Ved K, Shaikh S, Khanna S, Baar J, Dani J, Sahoo S, Soundharya R, Jolly MK, Verma N.   +12 more
europepmc   +1 more source

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

, 1991
Gary A. Koretzky, Joel Picus, TJ Schultz, A Weiss   +3 more
openalex   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Beyond expectations: investigating nilotinib's potential in attenuating neurodegeneration in alzheimer's disease. [PDF]

Alzheimers Res Ther
Tocci D, Fogel M, Gupta V, Kim P, Latimer J, Adlimoghaddam A, Robison LS, Albensi BC.   +7 more
europepmc   +1 more source