Results 251 to 260 of about 3,692,701 (303)

Protein Tyrosine Kinase Structure and Function

Annual Review of Biochemistry, 2000
▪ Abstract  Tyrosine phosphorylation is one of the key covalent modifications that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. The enzymes that carry out this modification are the protein tyrosine kinases (PTKs), which catalyze the transfer of the γ phosphate of ...
S R, Hubbard, J H, Till
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Non-receptor protein tyrosine kinases

Frontiers in Bioscience, 2003
The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides. Although phosphotransfer reactions catalyzed by various PTKs are similar with regard to their basic mechanisms, their biological functions demonstrate a considerable degree of ...
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Protein Tyrosine Kinase Activity Assays

Current Protocols in Pharmacology, 1999
AbstractProtein tyrosine kinases (PTKs) are ubiquitous enzymes that are integrally involved in the regulation of transformation mechanisms, normal and pathological growth, cell cycle regulation, immune responses, and a variety of intracellular signaling mechanisms.
B E, Hawes, T, van Biesen
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Structure and function of the protein tyrosine kinases

Progress in Growth Factor Research, 1990
The protein tyrosine kinases (PTKs) are a large and structurally diverse family of enzymes. The conserved catalytic domain held in common by each member of this family is a self-contained 250-300 amino acid unit bearing sixteen highly conserved linear sequence elements, several of which have been shown to be important to the catalytic activity of this ...
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Fertilization signalling and protein-tyrosine kinases

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000
Fertilization is initiated by species-specific gamete cell recognition, i.e. sperm-egg interaction, followed by a rapid and sustained activation of multiple cellular and biochemical events, collectively called 'egg activation', which is indispensable for successful formation of zygotic nucleus and later embryogenesis.
K, Sato, A A, Tokmakov, Y, Fukami
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Mechanisms of Transformation by Protein-Tyrosine Kinases

1988
In multicellular organisms there must be stringent control over the processes of cellular proliferation and differentiation. Thus sophisticated networks of regulatory molecules have evolved to sense and transmit signals within and between normal cells.
J C, Bell, L, Mahadevan, W H, Colledge, M J, Fry, A R, Frackelton, M G, Sargent, J G, Foulkes   +6 more
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Regulation of protein tyrosine kinases in platelets

Trends in Biochemical Sciences, 1994
Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated ...
E A, Clark, S J, Shattil, J S, Brugge
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Structural biology of protein tyrosine kinases

Cellular and Molecular Life Sciences, 2006
Our current understanding of the structure, mechanism of action and modes of regulation of the protein tyrosine kinase family owes a great deal to structural biology. Structures are now available for more than 20 different tyrosine kinase domains, many of these in multiple conformational states.
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src-related protein tyrosine kinases

1989
Tyrosine protein kinases (TPKs) catalyze the transfer of phosphate groups from nucleotide triphosphates to tyrosine residues on proteins and peptides. While phosphorylation of proteins on tyrosine residues is a well-known post-radiational event detected in different regulatory systems, only a small number of cellular proteins are known substrates for ...
A, Veillette, J B, Bolen
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PROTEIN-TYROSINE KINASES

Annual Review of Biochemistry, 1985
T, Hunter, J A, Cooper
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