Results 241 to 250 of about 328,904 (334)
A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer. [PDF]
Rangarajan A+5 more
europepmc +1 more source
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin+7 more
wiley +1 more source
Introduction to the themed collection on kinases. [PDF]
Jin M, Binch H, Heppner DE, Jones P.
europepmc +1 more source
CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee+13 more
wiley +1 more source
Quantitative profiling of protein tyrosine kinases in human cancer cell lines by multiplexed parallel reaction monitoring assays [PDF]
europepmc +1 more source
Herbal medicine, with its multicomponent and multitarget potential, is often studied primarily for traditional forms, especially phytochemicals. Currently, ulcerative colitis lacks natural, low‐toxicity therapies, yet emerging research highlights plant‐derived exosomes as a promising option.
Ruipeng Shi+9 more
wiley +1 more source
High-throughput proteome integral solubility alteration assay for low cell input using One-Tip. [PDF]
Lechner M, Sabatier P, Olsen JV.
europepmc +1 more source
Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu+18 more
wiley +1 more source
Post-translational modifications in anaplastic thyroid carcinoma: biological mechanisms and therapeutic potential. [PDF]
Zhong L+5 more
europepmc +1 more source