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Journal of the American Chemical Society, 2018
Molecules capable of monitoring receptor protein-tyrosine kinase expression could potentially serve as useful tools for cancer diagnosis due to the overexpression of tyrosine kinases during tumor growth and metastasis.
Yang Jiao +5 more
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Molecules capable of monitoring receptor protein-tyrosine kinase expression could potentially serve as useful tools for cancer diagnosis due to the overexpression of tyrosine kinases during tumor growth and metastasis.
Yang Jiao +5 more
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Inhibitors of protein tyrosine kinases
Current Opinion in Biotechnology, 1995The description in the past year of several novel protein tyrosine kinase inhibitors, which exhibit dramatic improvements in potency and specificity over earlier agents, will be considered a major turning point in the field. These compounds appear to have the necessary pharmacological properties to finally allow clarification of whether suppression of ...
David W. Fry, Alexander James Bridges
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Protein Tyrosine Kinase Activity Assays [PDF]
Current Protocols in Pharmacology, 1999 AbstractProtein tyrosine kinases (PTKs) are ubiquitous enzymes that are integrally involved in the regulation of transformation mechanisms, normal and pathological growth, cell cycle regulation, immune responses, and a variety of intracellular signaling mechanisms.
Brian E. Hawes, Tim van Biesen
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GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.
Science, 1991Binding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by glycophosphatidylinositol (GPI) can cause activation of leukocytes.
I. Štefanov́a +4 more
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Platelet Protein Tyrosine Kinases [PDF]
, 1997 The first protein tyrosine kinase (PTK) to be identified, detected by Hunter and Sefton in 1979, was the transforming protein of the Rous sarcoma virus (Hunter and Sefton 1980). This 60-kDa phosphoprotein is encoded by the viral src oncogene (v-src) and is denoted pp60 v-src .
E. A. Martinson, P. Presek
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6 Protein Tyrosine Kinase Inhibitors
1996Publisher Summary This chapter describes the classification and structure of protein tyrosine kinases (PTKs), their mode of action, their cellular targets, and the processes in which they are involved. A vast amount of research has been carried out to try to identify the role of PTKs in the general functioning and development of normal mammalian ...
Kevin R. H. Solomons +3 more
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Cytokine signaling through nonreceptor protein tyrosine kinases.
Science, 1995Cytokines are a family of soluble mediators of cell-to-cell communication that includes interleukins, interferons, and colony-stimulating factors. The characteristic features of cytokines lie in their functional redundancy and pleiotropy.
T. Taniguchi
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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Science, 1993A mouse phosphotyrosine phosphatase containing two Src homology 2 (SH2) domains, Syp, was identified. Syp bound to autophosphorylated epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors through its SH2 domains and was ...
G. Feng, C. Hui, T. Pawson
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Nuclear protein tyrosine kinases
Trends in Biochemical Sciences, 1994Protein tyrosine phosphorylation plays an important role in the transduction of extracellular signals. The prototypical protein tyrosine kinases are localized at the plasma membrane and are coupled to receptors that bind extracellular factors. Thus, protein tyrosine phosphorylation was previously thought to occur only in the cytoplasm. However, several
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Protein—Tyrosine Kinases and Their Substrates [PDF]
, 1990 Protein phosphorylation, through its ability to increase or decrease the activity of proteins, plays a central role in cellular regulation. Most proteins known to be regulated by phosphorylation are substrates for both a protein kinase and a protein phosphatase.
David S. Middlemas +5 more
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