Results 271 to 280 of about 938,417 (319)
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Annual Review of Immunology, 1994
Engagement of the T cell antigen receptor (TCR) by peptide antigen bound to the major histocompatibility complex (MHC) molecules initiates a biochemical cascade involving protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases). Recent
Andrew C. Chan, D. Desai, Arthur Weiss
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Engagement of the T cell antigen receptor (TCR) by peptide antigen bound to the major histocompatibility complex (MHC) molecules initiates a biochemical cascade involving protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases). Recent
Andrew C. Chan, D. Desai, Arthur Weiss
semanticscholar +1 more source
Protein Tyrosine Kinase Structure and Function
Annual Review of Biochemistry, 2000▪ Abstract Tyrosine phosphorylation is one of the key covalent modifications that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance of adult tissues. The enzymes that carry out this modification are the protein tyrosine kinases (PTKs), which catalyze the transfer of the γ phosphate of ...
Jeffrey H. Till, Stevan R. Hubbard
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Regulation of protein tyrosine kinases in platelets
Trends in Biochemical Sciences, 1994Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated ...
Edwin A. Clark +2 more
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International journal of peptide & protein research, 2009
Using a random combinatorial peptide library method [Wu, J., Ma, Q. N. & Lam, K. S. (1994) Biochemistry 33, 14825-14833] a novel peptide, YIYGSFK, was identified as a substrate for p60c-src protein tyrosine kinase. Mass spectrometric analysis showed that
K. Lam, J. Wu, Q. Lou
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Using a random combinatorial peptide library method [Wu, J., Ma, Q. N. & Lam, K. S. (1994) Biochemistry 33, 14825-14833] a novel peptide, YIYGSFK, was identified as a substrate for p60c-src protein tyrosine kinase. Mass spectrometric analysis showed that
K. Lam, J. Wu, Q. Lou
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Fertilization signalling and protein-tyrosine kinases
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000Fertilization is initiated by species-specific gamete cell recognition, i.e. sperm-egg interaction, followed by a rapid and sustained activation of multiple cellular and biochemical events, collectively called 'egg activation', which is indispensable for successful formation of zygotic nucleus and later embryogenesis.
Ken-ichi Sato +2 more
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Oncogenic protein tyrosine kinases
Cellular and Molecular Life Sciences, 2004Tyrosine kinases (TKs) and related molecules comprise over 100 different genes. Approximately two-thirds represent receptor TKs, the other third being non receptor TKs. TKs regulate important cellular signalling, from the transduction of extracellular signals to the regulation of key biological processes such as cell proliferation and apoptosis [1, 2].
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Self-reporting fluorescent substrates of protein tyrosine kinases.
Journal of the American Chemical Society, 2006A new mechanistic principle by which protein tyrosine kinase substrates fluorescently report the introduction of a phosphate moiety has been developed.
Qunzhao Wang +3 more
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Protein tyrosine kinases in thymocyte development
Current Opinion in Immunology, 1997Much has been learned over the past few years about how protein tyrosine kinases mediate pre-TCR and mature alphabetaTCR function. The highlights include understanding the roles and the distinct effects of the Src and Syk families of protein tyrosine kinases in thymocyte development and function.
Andrew C. Chan, Alec M. Cheng
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The c-Fes family of protein-tyrosine kinases.
Critical reviews in oncogenesis, 1998The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was ...
T. Smithgall +10 more
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Protein tyrosine kinases in malignant melanoma
Melanoma Research, 2000Protein tyrosyl phosphorylation is an essential component in intracellular signalling, with diverse and crucial functions including mediation of cell proliferation, survival, death, differentiation, migration and attachment. It is regulated by the balance between the activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases.
Dorothy C. Bennett, David J. Easty
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