Results 61 to 70 of about 184,784 (335)
Frontiers in Microbiology, 2014 Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Lei eShi +7 more
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Grb2 binding induces phosphorylation-independent activation of Shp2
Communications Biology, 2021 Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of ...
Chi-Chuan Lin +5 more
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Regulation of the Src protein tyrosine kinase
FEBS Letters, 1995 Members of the Src family of protein tyrosine kinases are involved in a variety of cellular processes, including cell growth, cell differentiation and neuronal signalling. N‐terminal to the catalytic domain, Src family members contain a Src homology 2 (SH2) domain, a Src homology 3 (SH3) domain, and a unique domain, all capable of protein‐protein ...
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A cytosolic protein tyrosine kinase in rat adipocytes [PDF]
FEBS Letters, 1992 Previous studies suggested that insulin receptor tyrosine kinase (IRTK) is the sole tyrosine kinase in rat adipocytes. We now report that this cell type also contains a cytosolic soluble protein tyrosine kinase (CytPTK) which is not related to IRTK. The enzyme phosphorylated PolyGlu4Tyr whith high efficiency at a rate of 20 ± 2 pmoI PTyr/20μg PolyGlu4 ...
Yoram Shechter, Assia Shisheva
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Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Current understanding of tyrosine kinase BMX in inflammation and its inhibitors
Burns & Trauma, 2014 Tec family kinases, which include tyrosine kinase expressed in hepatocellular carcinoma (TEC), Bruton's tyrosine kinase (BTK), interleukin (IL)-2-inducible T-cell kinase (ITK), tyrosine-protein kinase (TXK), and bone marrow tyrosine kinase on chromosome ...
Le Qiu, Fei Wang, Sheng Liu, Xu-Lin Chen
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
PLoS ONE, 2014 Breast tumor kinase (BRK), also known as protein tyrosine kinase 6 (PTK6), is a non-receptor tyrosine kinase overexpressed in more that 60% of human breast carcinomas.
Sayem Miah +7 more
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Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib [PDF]
Anais Brasileiros de Dermatologia, 2016 Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to ...
Juliana Ribeiro Leitão +4 more
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