Results 41 to 50 of about 3,948,731 (294)

Protein Tyrosine Kinase in Colorectal Adenoma [PDF]

Acta Oncologica, 1993
To determine whether protein tyrosine kinase (PTK) could be utilized as a biological indicator of colonic tumorigenesis, we examined the PTK activity in the cytosolic and particulate fractions of homogenates from 25 adenomas (polyps) and from adjacent normal mucosa.
T, Hatada, Y, Sakanoue, M, Kusunoki, H, Yanagi, T, Yamamura, J, Utsunomiya   +5 more
openaire   +2 more sources

Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells
Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
doaj   +1 more source

ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]

, 2004
Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core   +1 more source

Large‐scale phosphorylation mapping reveals the extent of tyrosine phosphorylation in Arabidopsis

Molecular Systems Biology, 2008
Protein phosphorylation regulates a wide range of cellular processes. Here, we report the proteome‐wide mapping of in vivo phosphorylation sites in Arabidopsis by using complementary phosphopeptide enrichment techniques coupled with high‐accuracy mass ...
Naoyuki Sugiyama, Hirofumi Nakagami, Keiichi Mochida, Arsalan Daudi, Masaru Tomita, Ken Shirasu, Yasushi Ishihama   +6 more
doaj   +1 more source

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B

Scientific Reports, 2022
The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding.
Marco Papenfuss, Svenja Lützow, Gerrit Wilms, Aaron Babendreyer, Maren Flaßhoff, Conrad Kunick, Walter Becker   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Recent Advances in Discovery of New Tyrosine Kinase Inhibitors Using Computational Methods

Proceedings, 2019
Tyrosine–protein kinases catalyze chemical reactions that. [...]
Vesna Rastija
doaj   +1 more source

Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. [PDF]

PLoS Computational Biology, 2015
Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment.
Juan Palacios-Moreno, Lauren Foltz, Ailan Guo, Matthew P Stokes, Emily D Kuehn, Lynn George, Michael Comb, Mark L Grimes   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source