Frontiers in Microbiology, 2014 Signal transduction in eukaryotes is generally transmitted through phosphorylation cascades that involve a complex interplay of transmembrane receptors, protein kinases, phosphatases and their targets.
Lei eShi +9 more
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The protein tyrosine kinases EpsB and PtkA differentially affect biofilm formation in Bacillus subtilis [PDF]
, 2014 The Gram-positive soil bacterium Bacillus subtilis is able to choose between motile and sessile lifestyles. The sessile way of life, also referred to as biofilm, depends on the formation of an extracellular polysaccharide matrix and some extracellular ...
Stanley-Wall, Nicola +6 more
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Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
F A, Al-Obeidi, K S, Lam
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Protein Tyrosine Kinase in Colorectal Adenoma [PDF]
Acta Oncologica, 1993 To determine whether protein tyrosine kinase (PTK) could be utilized as a biological indicator of colonic tumorigenesis, we examined the PTK activity in the cytosolic and particulate fractions of homogenates from 25 adenomas (polyps) and from adjacent normal mucosa.
T, Hatada +5 more
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Induction of phagocytosis by a protein tyrosine kinase [PDF]
Blood, 1995 The transmission of extracellular signals to cellular targets by many noncatalytic surface receptors is dependent on interaction between cytoplasmic protein tyrosine kinases (PTKs) and tyrosine-containing sequences in the cytoplasmic domain of the receptor or an associated subunit.
Zena K. Indik +3 more
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The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]
PLoS ONE, 2012 BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
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Phylogeny of Tec Family Kinases: Identification of a Pre-Metazoan Origin of Btk, Bmx, Itk, Tec, Txk and the Btk Regulator SH3BP5 [PDF]
, 2008 It is generally considered mammals and birds have five Tec family kinases (TFKs): Btk, Bmx (also known as Etk), Itk, Tec, and Txk (also known as Rlk). Here, we discuss the domains and their functions and regulation in TFKs.
Ortutay, Csaba +7 more
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Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]
, 2014 Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
Christoph S Clemen +23 more
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Protein-tyrosine phosphorylation in Bacillus subtilis: a 10-year retrospective
Frontiers in Microbiology, 2015 The discovery of tyrosine-phosphorylated proteins in Bacillus subtilis in the year 2003 was followed by a decade of intensive research activity. Here we provide an overview of the lessons learned in that period.
Josef eDeutscher, Ivan eMijakovic
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Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors
CellsProtein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
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