Results 21 to 30 of about 3,692,701 (303)
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 [PDF]
, 2002 Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S. +13 more
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Química Nova, 2009 Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues.
Bárbara V. Silva +3 more
doaj +1 more source
Deep evolutionary conservation of an intramolecular protein kinase activation mechanism [PDF]
, 2012 DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases.
Cleghon Vaughn +31 more
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The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]
PLoS ONE, 2012 BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
doaj +1 more source
Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
F A, Al-Obeidi, K S, Lam
openaire +2 more sources
ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]
, 2004 Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core +1 more source
JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]
, 2006 MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core +1 more source
MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers
Egyptian Journal of Medical Human Genetics, 2021 Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males.
Malihe Zangoue +3 more
doaj +1 more source
Protein-tyrosine phosphorylation in Bacillus subtilis: a 10-year retrospective
Frontiers in Microbiology, 2015 The discovery of tyrosine-phosphorylated proteins in Bacillus subtilis in the year 2003 was followed by a decade of intensive research activity. Here we provide an overview of the lessons learned in that period.
Josef eDeutscher, Ivan eMijakovic
doaj +1 more source
Protein Tyrosine Kinase in Colorectal Adenoma [PDF]
Acta Oncologica, 1993 To determine whether protein tyrosine kinase (PTK) could be utilized as a biological indicator of colonic tumorigenesis, we examined the PTK activity in the cytosolic and particulate fractions of homogenates from 25 adenomas (polyps) and from adjacent normal mucosa.
T, Hatada +5 more
openaire +2 more sources