Results 11 to 20 of about 207,434 (261)
eLife, 2023 Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities that depend on the amino acid sequence surrounding the target (phospho)tyrosine residue.
Allyson Li +4 more
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Protein tyrosine kinases in Schistosoma mansoni
Memorias do Instituto Oswaldo Cruz, 2006 The identification and description of signal transduction molecules and mechanisms are essential to elucidate Schistosoma mansoni host-parasite interactions and parasite biology.
Diana Bahia +4 more
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Tyrosine kinases in rheumatoid arthritis
Journal of Inflammation, 2011 Rheumatoid arthritis (RA) is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses
Kobayashi Akiko, Okamoto Hiroshi
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The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity
Cells, 2021 NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and ...
Jason Chekmarev +2 more
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Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
MedComm, 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang +10 more
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Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
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Química Nova, 2009 Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues.
Bárbara V. Silva +3 more
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The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]
PLoS ONE, 2012 BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
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Development of inhibitors for protein tyrosine kinases [PDF]
Oncogene, 2000 In the last 5 years, through combinatorial chemistry, high-throughput screening, computational chemistry, and traditional medicinal chemistry, numerous inhibitors for various protein tyrosine kinases (PTKs) have been developed. The majority of these compounds are small molecules that compete at the ATP binding site of the catalytic domain of the ...
F A, Al-Obeidi, K S, Lam
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MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers
Egyptian Journal of Medical Human Genetics, 2021 Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males.
Malihe Zangoue +3 more
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