Results 151 to 160 of about 15,507,347 (338)
, 2001 Among the proteins that have evolved over hundreds of millions of years, with important roles in defence against invading micro-organisms, are the pentraxins.
Hjorth, P
core
Protein-protein diffusional encounter
Biophysical Journal, 1997 Protein-protein association is clearly a very important process in biology, including events such as signal transduction, immune response, and transcription. Protein-protein association rates are in the range of 103 to 109 M-l S-1, with those in the diffusion-limited regime having rates of .106 M-1 s.
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FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
UniProt: the Universal Protein knowledgebase
Nucleic Acids Res., 2004 To provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information, the Swiss-Prot, TrEMBL and PIR protein database activities have united to form the Universal Protein Knowledgebase ...
R. Apweiler +14 more
semanticscholar +1 more source
Protein-Protein Interactions [PDF]
Revista Brasileira de Ciências Farmacêuticas, 2004 Graziella Pedrazzi, Igor Stagljar
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Cell Communication and Signaling, 2019 Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma membrane. FGFRs signaling needs to be precisely adjusted as aberrant FGFRs function is associated with development of human cancers or ...
Marika Kucińska +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Alpha-synuclein misfolding as fluid biomarker for Parkinson’s disease measured with the iRS platform
EMBO Molecular MedicineMisfolding and aggregation of alpha-synuclein (αSyn) play a key role in the pathophysiology of Parkinson’s disease (PD). Despite considerable advances in diagnostics, an early and differential diagnosis of PD still represents a major challenge.
Martin Schuler +19 more
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Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source