Serum Proteomic Profile Based on the TGF-β Pathway Stratifies Risk of Hepatocellular Carcinoma. [PDF]
Xiang X+19 more
europepmc +1 more source
Two-Dimensional Electrophoresis of Serum Proteins [PDF]
Oliver Smithies, M. D. Poulik
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In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim+11 more
wiley +1 more source
High Molecular Crowding in Repair Foci Surrounding DNA Breaks, Measured by Fluorescence Lifetime Imaging Microscopy. [PDF]
Levchenko SM, Dobrucki JW.
europepmc +1 more source
The influence of energy intake on protein metabolism [PDF]
Hamish N. Munro, D. J. Naismith
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
wiley +1 more source
The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases. [PDF]
Anguraj Vadivel AK+9 more
europepmc +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source
Algae-dominated metaproteomes uncover cellular adaptations to life on the Greenland Ice Sheet. [PDF]
Feord HK+13 more
europepmc +1 more source
SECOND REPORT ON BARLEY PROTEINS: COMPOSITION AND QUANTITATIVE ESTIMATION OF THE BARLEY PROTEINS.-II
L. R. Bishop
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