Targeting Galectins With Glycomimetics [PDF]
Frontiers in Chemistry, 2020 Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Jesus Jiménez-Barbero +2 more
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Placental Galectins in Cancer: Why We Should Pay More Attention [PDF]
Cells, 2023 The first studies suggesting that abnormal expression of galectins is associated with cancer were published more than 30 years ago. Today, the role of galectins in cancer is relatively well established.
Yves St-Pierre, Nicolas Doucet
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The role of galectins in virus infection - A systemic literature review
Journal of Microbiology, Immunology and Infection, 2020 Background: Galectins are β-Galactose binding lectins expressed in numerous cells and play multiple roles in various physiological and cellular functions. However, few information is available regarding the role of galectins in virus infections. Here, we
Yenhsu Chen +2 more
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Biomolecules, 2020 Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions.
Diego Läderach, Daniel Compagno
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Inhibition of galectins in cancer: Biological challenges for their clinical application
Frontiers in Immunology, 2023 Galectins play relevant roles in tumor development, progression and metastasis. Accordingly, galectins are certainly enticing targets for medical intervention in cancer. To date, however, clinical trials based on galectin inhibitors reported inconclusive
Diego Läderach, Daniel Compagno
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Glycobiology-driven therapeutic targeting of glycan-binding proteins: mechanisms, diseases, and clinical translation [PDF]
Signal Transduction and Targeted TherapyGalectins are glycan-binding proteins that interact with diverse glycoconjugates and protein networks to regulate intracellular and extracellular signaling pathways governing fundamental biological processes.
Alyanna M. Popatia +2 more
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Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
Journal of Biomedical Science, 2021 Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged ...
Ming-Hsiang Hong +4 more
doaj +1 more source
Galectin functions in cancer-associated inflammation and thrombosis
Frontiers in Cardiovascular Medicine, 2023 Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical evidence indicates that galectins influence many steps of cancer ...
Linus Kruk +7 more
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Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy
Biomarker Research, 2023 Galectins are animal lectins with specific affinity for galactosides via the conserved carbohydrate recognition domains. Increasing studies recently have identified critical roles of galectin family members in tumor progression.
Dan Liu, Hongtao Zhu, Chuanzhou Li
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Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and Neoplasia [PDF]
Journal of Pathology and Translational Medicine, 2015 Galectins are an evolutionarily ancient and widely expressed family of lectins that have unique glycan-binding characteristics. They are pleiotropic regulators of key biological processes, such as cell growth, proliferation, differentiation, apoptosis ...
Nandor Gabor Than +9 more
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