Results 41 to 50 of about 9,887 (270)
Cellular and Molecular Life Sciences CMLS, 2006 Galectins are a family of animal lectins with an affinity for beta-galactosides. They are differentially expressed by various tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development and in adult tissue.
Saussez, Sven, Kiss, Robert
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mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain
Frontiers in Molecular Neuroscience, 2016 Background: Galectins, a family of non-classically secreted, β-galactoside binding proteins is involved in several brain disorders; however no systematic knowledge on the normal neuroanatomical distribution and functions of galectins exits.
Sebastian John, Rashmi Mishra
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Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer [PDF]
, 2005 Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers.
Szöke, Tamas +9 more
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Galectin-2, Galectins-5 and -9, and Galectins-4 and -6.
Trends in Glycoscience and Glycotechnology, 1997 現在、哺乳類には10種類のガレクチンがあることが示されている。この章ではそのうち5つについて、各ガレクチンの発見の経緯と特徴について述べようと思う。ガレクチン-2はガレクチン-1と同様、14kDaのサブユニットが2量体構造をした分子で、腸上皮細胞に発現している。ガレクチン-5は15kDaの単量体ガレクチンで、赤血球に発現している。最近発見されたガレクチン-9は多くの組織で発現している36kDaのタンパク質で、2つの糖認識ドメイン (CRD) からなり、このうちC-末端側のCRDがガレクチン-5と非常に高い類似性を示す。ガレクチン-4と-6は互いにきわめて似た分子で、それぞれ36kDaと34kDaの分子量を持ち、やはりともに2つのCRDからなり、両者とも消化管の上皮細胞で発現している。
Gitt, Michael A. +2 more
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The Galectins as Targets for Cancer Therapeutics [PDF]
, 2013 The galectins are the most ancient and widely expressed family of glycan-binding protein, and have been found in all metazoans examined to date. Galectins recognise and bind to carbohydrate ligands, specifically those that contain [beta]-galactosides ...
Collins, Patrick
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Advanced high-affinity glycoconjugate ligands of galectins
, 2023 International audienceGalectins are proteins of the family of human lectins. By binding terminal galactose units of cell surface glycans, they moderate biological and pathological processes such as cell signaling, cell adhesion, apoptosis, fibrosis ...
Bumba, Ladislav +8 more
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Targeting intracellular galectins for cancer treatment
Frontiers in Immunology, 2023 Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their ...
Rita Nehmé, Yves St-Pierre
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Galectin-8 and galectin-9 are novel substrates for thrombin [PDF]
Glycobiology, 2006 Galectin-8 and galectin-9, which each consist of two carbohydrate recognition domains (CRDs) joined by a linker peptide, belong to the tandem-repeat-type subclass of the galectin family. Alternative splicing leads to the formation of at least two and three distinct splice variants (isoforms) of galectin-8 and galectin-9, respectively, with tandem ...
Nozomu, Nishi +4 more
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Characterization of Galectin Fusion Proteins with Glycoprotein Affinity Columns and Binding Assays
Molecules, 2023 Galectins are β-galactosyl-binding proteins that fulfill essential physiological functions. In the biotechnological field, galectins are versatile tools, such as in the development of biomaterial coatings or the early-stage diagnosis of cancer diseases ...
Carina Dey, Philip Palm, Lothar Elling
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Evaluation of the role of galectins in parasite immunity
, 2014 Galectin-11 and galectin-14 are ruminant galectins involved in parasitic infections. Although their roles in parasite immunity are still being elucidated, its appears that their functions are parasite specific.
Beddoe, Travis +9 more
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