Results 21 to 30 of about 9,887 (270)

Galectins - Important players of the immune response to CNS parasitic infection

Brain, Behavior, & Immunity - Health, 2021
Galectins are a family of proteins that bind β-galactosides and play key roles in a variety of cellular processes including host defense and entry of parasites into the host cells. They have been well studied in hosts but less so in parasites.
Marta Maruszewska-Cheruiyot, Michael Stear, Katarzyna Donskow-Łysoniewska   +2 more
doaj   +1 more source

Exploration of Galectin Ligands Displayed on Gram-Negative Respiratory Bacterial Pathogens with Different Cell Surface Architectures

Biomolecules, 2021
Galectins bind various pathogens through recognition of distinct carbohydrate structures. In this work, we examined the binding of four human galectins to the Gram-negative bacteria Klebsiella pneumoniae (Kpn) and non-typeable Haemophilus influenzae ...
María A. Campanero-Rhodes, Ioanna Kalograiaki, Begoña Euba, Enrique Llobet, Ana Ardá, Jesús Jiménez-Barbero, Junkal Garmendia, Dolores Solís   +7 more
doaj   +1 more source

Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]

, 2020
In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Neus, Martínez-Bosch, Pilar, Navarro
openaire   +2 more sources

Galectin-1 and Galectin-3 in Chronic Pancreatitis [PDF]

Laboratory Investigation, 2000
Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined their expression by Northern blot analysis, in situ hybridization, immunohistochemistry, and ...
Wang L, Friess H, Zhu Z, Frigeri L, Zimmermann A, Korc M, Berberat PO, Büchler MW   +7 more
openaire   +3 more sources

Association between high galectin expression and poor prognosis in hematologic cancers: a systematic review and meta-analysis

Hematology, 2023
Background Galectin (Gal) is considered a promising immune checkpoint molecule. More and more studies have shown that high expression levels of galectins in hematologic cancer are positively correlated with poor clinical prognosis.
Haotian Liu, Qiuying Dai, Yixian Li, Zhenfei Tang, Tiantian She   +4 more
doaj   +1 more source

Degraded Arabinogalactans and Their Binding Properties to Cancer-Associated Human Galectins [PDF]

, 2021
Galectins represent β-galactoside-binding proteins with numerous functions. Due to their role in tumor progression, human galectins-1, -3 and -7 (Gal-1, -3 and -7) are potential targets for cancer therapy.
Alexander Baumann, Bastian Höger, Pfeifer, Lukas, Baumann, Alexander, Birgit Classen, Lea Madlen Petersen, Eric Beitz, Lukas Pfeifer, Classen, Birgit, Beitz, Eric, Höger, Bastian Thomas, Petersen, Lea Madlen   +11 more
core   +1 more source

Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

Frontiers in Immunology, 2019
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function.
Sandra M. Blois, Sandra M. Blois, Gabriela Dveksler, Gerardo R. Vasta, Nancy Freitag, Véronique Blanchard, Gabriela Barrientos   +6 more
doaj   +1 more source

The Role of Galectins in Chronic Lung Allograft Dysfunction [PDF]

, 2021
Galectins are proteins that bind β-galactosides such as N-acetyllactosamine present in N-linked and O-linked glycoproteins and that seem to be implicated in inflammatory and immune responses as well as fibrotic mechanisms.
Paladini, Piero, Bargagli, Elena, De Vita, Elda, Fossi, Antonella, Sestini, Piersante, Bergantini, Laura, Luzzi, Luca, d'Alessandro, Miriana, Bennett, David, Perillo, Felice, Rottoli, Paola, Luca Luzzi, Felice Perillo, Miriana d’Alessandro, Laura Bergantini, Antonella Fossi, David Bennett, Elda De Vita, Elena Bargagli, Piero Paladini, Piersante Sestini, Paola Rottoli   +21 more
core   +1 more source

Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling

Cell Communication and Signaling, 2023
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body.
Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski, Lukasz Opalinski   +9 more
doaj   +1 more source

Simulating cellular galectin networks by mixing galectins in vitro reveals synergistic activity

Biochemistry and Biophysics Reports, 2021
Background: Even though members of the family of adhesion/growth-regulatory galectins are increasingly detected to be co-expressed, they are still being routinely tested separately. The recent discovery of heterodimer formation among galectins-1, -3, and
Ruud P.M. Dings, Nigam Kumar, Sterling Mikkelson, Hans-Joachim Gabius, Kevin H. Mayo   +4 more
doaj   +1 more source