Results 21 to 30 of about 7,165 (232)
Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
Frontiers in Immunology, 2019 Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function.
Sandra M. Blois +6 more
doaj +1 more source
World Journal of Surgical Oncology, 2022 Background and aim Galectins have been recently tackled by many researchers in the field of cancer due to their role in tumorigenesis, disease progression, and metastasis.
Radwa Mansour Mohamed +5 more
doaj +1 more source
Simulating cellular galectin networks by mixing galectins in vitro reveals synergistic activity
Biochemistry and Biophysics Reports, 2021 Background: Even though members of the family of adhesion/growth-regulatory galectins are increasingly detected to be co-expressed, they are still being routinely tested separately. The recent discovery of heterodimer formation among galectins-1, -3, and
Ruud P.M. Dings +4 more
doaj +1 more source
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
doaj +1 more source
A Synthetic Galectin Mimic [PDF]
Angewandte Chemie, 2021 AbstractGalectins are a galactoside specific subclass of carbohydrate binding proteins (lectins) involved in various cellular activities, certain cancers, infections, inflammations, and many other biological processes. The molecular basis for the selectivity of galectins is well‐documented and revolves around appropriate interaction complementarity: an
Brian J. J. Timmer +3 more
openaire +6 more sources
Comparative analysis of galectin-1, galectin-3, and galectin-8 signatures in normal and choriocarcinoma trophoblast cell lines [PDF]
Archives of Biological SciencesGalectins are found in the placenta during both normal and pathological conditions. Specifically, galectins -1, -3, and -8 have been identified in extravillous trophoblast cells, with galectins -1, and -3 playing notable roles in trophoblast cell ...
Jovanović Krivokuća Milica +6 more
doaj +1 more source
Pharmaceuticals, 2021 Animal lectins are proteins with carbohydrate recognition activity. Galectins, the β-galactoside binding lectins, are expressed in various cells and have been reported to regulate several immunological and physiological responses.
Chih-Yen Lin +7 more
doaj +1 more source
Cellular and Molecular Life Sciences CMLS, 2006 Galectins are a family of animal lectins with an affinity for beta-galactosides. They are differentially expressed by various tissues and appear to be functionally multivalent, exerting a wide range of biological activities both during development and in adult tissue.
Saussez, Sven, Kiss, Robert
openaire +4 more sources
Galectin-2, Galectins-5 and -9, and Galectins-4 and -6.
Trends in Glycoscience and Glycotechnology, 1997 現在、哺乳類には10種類のガレクチンがあることが示されている。この章ではそのうち5つについて、各ガレクチンの発見の経緯と特徴について述べようと思う。ガレクチン-2はガレクチン-1と同様、14kDaのサブユニットが2量体構造をした分子で、腸上皮細胞に発現している。ガレクチン-5は15kDaの単量体ガレクチンで、赤血球に発現している。最近発見されたガレクチン-9は多くの組織で発現している36kDaのタンパク質で、2つの糖認識ドメイン (CRD) からなり、このうちC-末端側のCRDがガレクチン-5と非常に高い類似性を示す。ガレクチン-4と-6は互いにきわめて似た分子で、それぞれ36kDaと34kDaの分子量を持ち、やはりともに2つのCRDからなり、両者とも消化管の上皮細胞で発現している。
Gitt, Michael A. +2 more
openaire +2 more sources
The Role of Galectins as Modulators of Metabolism and Inflammation
Mediators of Inflammation, 2018 Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to ...
Monica Fengsrud Brinchmann +2 more
doaj +1 more source