Results 11 to 20 of about 7,165 (232)
Targeting Galectins With Glycomimetics [PDF]
Frontiers in Chemistry, 2020 Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Sara Bertuzzi +6 more
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Current Biology, 2022 Banfer and Jacob introduce us to galectins - β-galactoside-binding lectins - and their range of functions in multicellular organisms.
Sebastian, Bänfer, Ralf, Jacob
+7 more sources
Journal of Cell Science, 2018 ABSTRACT Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease.
Johannes, Ludger +2 more
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Brain Pathology, 2009 AbstractMalignant gliomas, especially glioblastomas, are associated with a dismal prognosis. Despite advances in diagnosis and treatment, glioblastoma patients still have a median survival expectancy of only 14 months. This poor prognosis can be at least partly explained by the fact that glioma cells diffusely infiltrate the brain parenchyma and ...
Le Mercier, Marie +4 more
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Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]
, 2020 In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Martínez-Bosch, Neus +1 more
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Biomolecules, 2021 Galectins bind various pathogens through recognition of distinct carbohydrate structures. In this work, we examined the binding of four human galectins to the Gram-negative bacteria Klebsiella pneumoniae (Kpn) and non-typeable Haemophilus influenzae ...
María A. Campanero-Rhodes +7 more
doaj +1 more source
Galectin-1 and Galectin-3 in Chronic Pancreatitis [PDF]
Laboratory Investigation, 2000 Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined their expression by Northern blot analysis, in situ hybridization, immunohistochemistry, and ...
Wang L +7 more
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Role of Human Galectins in Inflammation and Cancers Associated with Endometriosis
Biomolecules, 2020 Galectins are a family of β-galactoside-binding proteins that contribute to multiple cellular functions, including immune surveillance and apoptosis.
Brooke V. Hisrich +6 more
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Cell Communication and Signaling, 2023 Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body.
Aleksandra Gedaj +9 more
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Hematology, 2023 Background Galectin (Gal) is considered a promising immune checkpoint molecule. More and more studies have shown that high expression levels of galectins in hematologic cancer are positively correlated with poor clinical prognosis.
Haotian Liu +4 more
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