Results 11 to 20 of about 9,659 (276)
Current Biology, 2022 Banfer and Jacob introduce us to galectins - β-galactoside-binding lectins - and their range of functions in multicellular organisms.
Sebastian, Bänfer, Ralf, Jacob
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Journal of Cell Science, 2018 ABSTRACT Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease.
Johannes, Ludger +2 more
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Galectins and cutaneous immunity [PDF]
Dermatologica Sinica, 2012 Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different
Huan-Yuan Chen +4 more
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Brain Pathology, 2009 AbstractMalignant gliomas, especially glioblastomas, are associated with a dismal prognosis. Despite advances in diagnosis and treatment, glioblastoma patients still have a median survival expectancy of only 14 months. This poor prognosis can be at least partly explained by the fact that glioma cells diffusely infiltrate the brain parenchyma and ...
Le Mercier, Marie +4 more
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Utilization of Galectins by Pathogens for Infection
Frontiers in Immunology, 2020 Galectins are glycan-binding proteins which are expressed by many different cell types and secreted extracellularly. These molecules are well-known regulators of immune responses and involved in a broad range of cellular and pathophysiological functions.
Diyoly Ayona +5 more
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2002 The galectins are a family of proteins that are distributed widely in all living organisms. All of them share galactose-specificity. At present, 14 members of the family are characterized in mammals. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth
Danguy, André +2 more
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The Role of Galectins as Modulators of Metabolism and Inflammation [PDF]
Mediators of Inflammation, 2018 Galectins are β-galcotosid-binding lectins. The function of galectins varies with their tissue-specific and subcellular location, and their binding to carbohydrates makes them key players in several intra- and extracellular processes where they bind to ...
Monica Fengsrud Brinchmann +2 more
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Targeting intracellular galectins for cancer treatment [PDF]
Frontiers in Immunology, 2023 Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their ...
Rita Nehmé, Yves St-Pierre
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Galectins in Atherosclerotic Disease
Trends in Cardiovascular Medicine, 2009 Although cells constantly adapt to external humoral cues, like cytokines and hormones, in practice, most cellular behavior is under locally guided control, via cell-cell interactions. The most prominent members of this group of molecules involved in this intercellular signaling are the galectins, a family of carbohydrate-binding proteins, which by ...
Sali, Al-Ansari +4 more
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Galectins in hematological malignancies [PDF]
Current Opinion in Hematology, 2013 Galectins are a family of lectin molecules that have emerged as key players in inflammation and tumor progresssion by displaying intracellular and extracellular activities. This review describes the recent advances on the role of galectins in hematological neoplasms.Galectin-1 and galectin-3 are the best studied galectins in oncohematology.
Giordano, Mirta Nilda +2 more
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