Results 31 to 40 of about 7,165 (232)
Galectins and cutaneous immunity
Dermatologica Sinica, 2012 Galectins are highly expressed in epithelial cells and immune cells. In skin, they can be detected in keratinocytes, melanocytes, dendritic cells, macrophages, and T cells. Galectins are present outside and inside the cells and thus may exhibit different
Huan-Yuan Chen +4 more
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Galectin-8 and galectin-9 are novel substrates for thrombin [PDF]
Glycobiology, 2006 Galectin-8 and galectin-9, which each consist of two carbohydrate recognition domains (CRDs) joined by a linker peptide, belong to the tandem-repeat-type subclass of the galectin family. Alternative splicing leads to the formation of at least two and three distinct splice variants (isoforms) of galectin-8 and galectin-9, respectively, with tandem ...
Nozomu, Nishi +4 more
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mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain
Frontiers in Molecular Neuroscience, 2016 Background: Galectins, a family of non-classically secreted, β-galactoside binding proteins is involved in several brain disorders; however no systematic knowledge on the normal neuroanatomical distribution and functions of galectins exits.
Sebastian John, Rashmi Mishra
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Targeting intracellular galectins for cancer treatment
Frontiers in Immunology, 2023 Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their ...
Rita Nehmé, Yves St-Pierre
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Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR) [PDF]
International Journal of Molecular Sciences, 2016 Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth ...
Stefan Hutter +7 more
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NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
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Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
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Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma
Liver Research, 2020 Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans. Abnormal expression of Gals is associated with the development, progression, and metastasis of different types of cancer. Among the 11 Gals identified in humans, the roles of Gal-1 and Gal-3 have been extensively investigated in various tumors.
Setayesh, Tahereh +2 more
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Characterization of Galectin Fusion Proteins with Glycoprotein Affinity Columns and Binding Assays
Molecules, 2023 Galectins are β-galactosyl-binding proteins that fulfill essential physiological functions. In the biotechnological field, galectins are versatile tools, such as in the development of biomaterial coatings or the early-stage diagnosis of cancer diseases ...
Carina Dey, Philip Palm, Lothar Elling
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Galectin-1 for Neuroprotection? [PDF]
Immunity, 2012 Classically activated microglia (M1) are believed to play a key role in neuronal degeneration in multiple sclerosis (MS). In this issue of Immunity, Starossom et al. (2012) show that Galectin-1 exerts a neuroprotective function through glycosylation-dependent inactivation with M1 cells.
Nonaka, Motohiro, Fukuda, Minoru
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