Results 31 to 40 of about 9,887 (270)

Assessment of galectins -1, -3, -4, -8, and -9 expression in ovarian carcinoma patients with clinical implications

World Journal of Surgical Oncology, 2022
Background and aim Galectins have been recently tackled by many researchers in the field of cancer due to their role in tumorigenesis, disease progression, and metastasis.
Radwa Mansour Mohamed, Athar Emam, Mahmoud M. Abdelfattah, Abdel-Mageed Ismail Abdel-Mageed, Mohamed A. Abdelhafeez, Reham Helwa   +5 more
doaj   +1 more source

Galectins: structure, function and therapeutic potential [PDF]

, 2008
Galectins are a family of animal lectins that bind beta-galactosides. Outside the cell, galectins bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular processes.
Fu Tong, Liu, Rabinovich, Gabriel Adrián, Ri Yao, Yang, Ri-Yao Yang, Fu-Tong Liu, Gabriel A. Rabinovich   +5 more
core   +1 more source

A Synthetic Galectin Mimic [PDF]

Angewandte Chemie, 2021
AbstractGalectins are a galactoside specific subclass of carbohydrate binding proteins (lectins) involved in various cellular activities, certain cancers, infections, inflammations, and many other biological processes. The molecular basis for the selectivity of galectins is well‐documented and revolves around appropriate interaction complementarity: an
Brian J. J. Timmer, Arjaan Kooijman, Xander Schaapkens, Tiddo J. Mooibroek   +3 more
openaire   +6 more sources

Low-Molecular Weight Inhibitors of Galectins

, 2012
The galectins are known to be able to recognize and cross-link beta-D-galactopyranoside-containing glycoconjugates as a result of presenting multiple binding sites.
Nilsson, Ulf,, Lund University., Leffler, Hakon,   +2 more
core   +2 more sources

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]

, 2011
Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
Lacina, Lukas, André, Sabine, Kaltner, Herbert, Karel Smetana, Jr., Gabius, Hans-Joachim, Peter Gal, Szabo, Pavol, Eva Sykova, Gal, Peter, Zima, Tomas, Sabine André, Tomas Zima, Smetana, Karel, Pavol Szabo, Barbora Dvořánková, Dvorankova, Barbora, Hans-Joachim Gabius, Jana Uhrova, Sykova, Eva, Lukas Lacina, Uhrova, Jana, Herbert Kaltner   +21 more
core   +1 more source

Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

Frontiers in Oncology, 2022
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi, Yuanwei Shi, Danting Tang, Danting Tang, Xiaoqi Li, Xiaoqi Li, Xiaoli Xie, Yufu Ye, Yufu Ye, Lijuan Wang, Lijuan Wang   +10 more
doaj   +1 more source

Comparative analysis of galectin-1, galectin-3, and galectin-8 signatures in normal and choriocarcinoma trophoblast cell lines [PDF]

Archives of Biological Sciences
Galectins are found in the placenta during both normal and pathological conditions. Specifically, galectins -1, -3, and -8 have been identified in extravillous trophoblast cells, with galectins -1, and -3 playing notable roles in trophoblast cell ...
Jovanović Krivokuća Milica, Legner Janko, Ćujić Danica, Vilotić Aleksandra, Grubiša Ivana, Vićovac Ljiljana, Bojić-Trbojević Žanka   +6 more
doaj   +1 more source

The Antiviral Role of Galectins toward Influenza A Virus Infection—An Alternative Strategy for Influenza Therapy

Pharmaceuticals, 2021
Animal lectins are proteins with carbohydrate recognition activity. Galectins, the β-galactoside binding lectins, are expressed in various cells and have been reported to regulate several immunological and physiological responses.
Chih-Yen Lin, Zih-Syuan Yang, Wen-Hung Wang, Aspiro Nayim Urbina, Yu-Ting Lin, Jason C. Huang, Fu-Tong Liu, Sheng-Fan Wang   +7 more
doaj   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source