Results 51 to 60 of about 13,626 (296)

Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials

Biomolecules, 2020
Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions.
Daniel Compagno, Carolina Tiraboschi, José Daniel Garcia, Yorfer Rondón, Enrique Corapi, Carla Velazquez, Diego José Laderach   +6 more
doaj   +1 more source

Functions of cell surface galectin-glycoprotein lattices [PDF]

, 2007
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for beta-
Jackson, Shawn S., Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, Gerardo R.   +3 more
core   +1 more source

Les galectines [PDF]

médecine/sciences, 2015
Galectins constitute a family of soluble animal lectins defined by their evolutionary conserved carbohydrate recognition domain and their affinity for β-galactosides containing glycoconjugates. Each galectin is characterized by a specific spatio-temporal distribution and a unique set of ligands and molecular partners. Interestingly, galectins are found
Tamara Advedissian, Frédérique Deshayes, Françoise Poirier, Cyrille Grandjean, Mireille Viguier   +4 more
openaire   +4 more sources

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed, Chavez, Leonard, Chew, Glen M, Danesh, Ali, Deeks, Steven G, Deng, Xutao, Hirashima, Mitsuomi, Hoh, Rebecca, Keating, Sheila, Lanteri, Marion, Ndhlovu, Lishomwa C, Niki, Toshiro, Norris, Philip J, Pillai, Satish K, Sacha, Jonah B, Samuels, Michael L, Shikuma, Cecilia M, Tandon, Ravi   +17 more
core   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical applications, challenges, and future directions

Arthritis Care &Research, Accepted Article.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation

Cells, 2020
Galectins are a family of soluble β-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions outside and inside the cell.
Rada Tazhitdinova, Alexander V. Timoshenko   +1 more
doaj   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira, Anders, Bjorge, Camby, Caminschi, Christoph Römmele, Elola, Ferwerda, Geijtenbeek, Gingras, Gringhuis, Gross, Hans-Joachim Anders, Heil, Heni Eka Susanti, Hornung, Kimbrell, Kock, Kono, Kronin, Kulkarni, Lassen, Lech, Lech, Lech, Lopez-Guisa, Maciej Lech, Medzhitov, Mocsai, Osorio, Patole, Rakoff-Nahoum, Regina Gröbmayr, Roman Günthner, Schreibelt, Skuginna, Van Vliet, Wagner, Zarember, Zhang   +39 more
core   +5 more sources

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source