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Expression of Concern: Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

Molecular Oncology, EarlyView.
wiley   +1 more source

Correction to “The polyamine transporter ATP13A3 mediates difluoromethylornithine‐induced polyamine uptake in neuroblastoma”

Molecular Oncology, EarlyView.
wiley   +1 more source

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Protein–protein interactions

Biochemical Society Transactions, 2010
In the present article, we describe the two standard high-throughput methods for identification of protein complexes: two-hybrid screens and TAP (tandem affinity purification) tagging. These methods have been used to characterize the interactome of Saccharomyces cerevisiae, showing that the majority of proteins are part of complexes, and that complexes
Williamson, Mike P., Sutcliffe, Michael J.   +1 more
openaire   +4 more sources

Analysis of Protein-Protein Interactions by Protein Microarrays

2021
The analysis of the proteome and the interactome would be useful for a better understanding of the pathophysiology of several disorders, allowing the identification of potential specific markers for early diagnosis and prognosis, as well as potential targets of intervention.
Rodrigo Barderas, Ana Montero-Calle
openaire   +3 more sources

Protein myristoylation in protein–lipid and protein–protein interactions

Biophysical Chemistry, 1999
Various proteins in signal transduction pathways are myristoylated. Although this modification is often essential for the proper functioning of the modified protein, the mechanism by which the modification exerts its effects is still largely unknown. Here we discuss the roles played by protein myristoylation, in both protein-lipid and protein-protein ...
openaire   +3 more sources

The impact of protein flexibility on protein–protein docking

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractAccounting for protein flexibility in protein–protein docking algorithms is challenging, and most algorithms therefore treat proteins as rigid bodies or permit side‐chain motion only. While the consequences are obvious when there are large conformational changes upon binding, the situation is less clear for the modest conformational changes ...
Rebecca C. Wade, Lutz P. Ehrlich, Michael Nilges   +2 more
openaire   +3 more sources

Protein–protein association kinetics and protein docking

Current Opinion in Structural Biology, 2002
Rigid body protein docking methods frequently yield false positive structures that have good surface complementarity, but are far from the native complex. The main reason for this is the uncertainty of the protein structures to be docked, including the positions of solvent-exposed sidechains. Substantial efforts have been devoted to finding near-native
Sandor Vajda, Carlos J. Camacho
openaire   +3 more sources

Protein-Protein Interactions in Membranes

Protein & Peptide Letters, 2011
In this article we review the current status of our understanding of membrane mediated interactions from theory and experiment. Phenomenological mean field and molecular models will be discussed and compared to recent experimental results from dynamical neutron scattering and atomic force microscopy.
Armstrong, C.L., Sandqvist, E., Rheinstädter, M.C.   +2 more
openaire   +3 more sources

Protein Phosphorylation and Protein-Protein Interactions

2002
Intracellular signaling is the series of events which translates the specific message of circulating ligands into a particular biological response in target cells. The first step in hormone signaling involves the interaction between a ligand and its cognate receptor (membrane or nuclear), which in turn induces stoichiometric and conformational changes ...
Paul A. Kelly, Vincent Goffin
openaire   +2 more sources

DISCOVERING PROTEIN–PROTEIN INTERACTIONS

Journal of Bioinformatics and Computational Biology, 2004
The ongoing genomics and proteomics efforts have helped identify many new genes and proteins in living organisms. However, simply knowing the existence of genes and proteins does not tell us much about the biological processes in which they participate. Many major biological processes are controlled by protein interaction networks.
See-Kiong Ng, Soon-Heng Tan
openaire   +2 more sources