Results 81 to 90 of about 15,507,347 (338)
Role of anisotropy for protein-protein encounter [PDF]
, 2010 Protein-protein interactions comprise both transport and reaction steps. During the transport step, anisotropy of proteins and their complexes is important both for hydrodynamic diffusion and accessibility of the binding site.
Korn, Christian B. +2 more
core +1 more source
InterProScan 5: genome-scale protein function classification
Bioinform., 2014 Motivation: Robust large-scale sequence analysis is a major challenge in modern genomic science, where biologists are frequently trying to characterize many millions of sequences.
Philip Jones +16 more
semanticscholar +1 more source
ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB.
Journal of Chemical Theory and Computation, 2015 Molecular mechanics is powerful for its speed in atomistic simulations, but an accurate force field is required. The Amber ff99SB force field improved protein secondary structure balance and dynamics from earlier force fields like ff99, but weaknesses in
James Maier +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Scientific Reports, 2019 DNA replication is initiated at replication origins on chromosomes at their scheduled time during S phase of the cell cycle. Replication timing control is highly conserved among eukaryotes but the underlying mechanisms are not fully understood.
Yudai Hasegawa +3 more
doaj +1 more source
Binary Assignments of Amino Acids from Pattern Conservation
, 1997 We develop a simple optimization procedure for assigning binary values to the amino acids. The binary values are determined by a maximization of the degree of pattern conservation in groups of closely related protein sequences.
Irbäck, Anders, Potthast, Frank
core +5 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The Pfam protein families database in 2019
Nucleic Acids Res., 2018 The last few years have witnessed significant changes in Pfam (https://pfam.xfam.org). The number of families has grown substantially to a total of 17,929 in release 32.0.
Sara El-Gebali +15 more
semanticscholar +1 more source
Communications ChemistryCovalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity.
Isabel R. Mathiesen +3 more
doaj +1 more source