Results 81 to 90 of about 10,756,110 (307)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Investigation of Functional-technological Properties of Soya Protein [PDF]

, 2018
There was offered and grounded the use of functional technological properties of the soya protein isolate in the technology of oil pasts. It will allows to increase the balance of the oil past composition additionally and will favor the decrease of ...
Kochubei-Lytvynenko, O. (Oksana), Kuzmyk, U. (Ulyana), Yatsenko, O. (Olha), Yushchenko, N. (Nataliia)   +3 more
core   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Replication protein-A, RPA, plays a pivotal role in the maintenance of recombination checkpoint in yeast meiosis

Scientific Reports
DNA double-strand breaks (DSBs) activate DNA damage responses (DDRs) in both mitotic and meiotic cells. A single-stranded DNA (ssDNA) binding protein, Replication protein-A (RPA) binds to the ssDNA formed at DSBs to activate ATR/Mec1 kinase for the ...
Arivarasan Sampathkumar, Chen Zhong, Yuting Tang, Yurika Fujita, Masaru Ito, Akira Shinohara   +5 more
doaj   +1 more source

Side-chain conformational changes upon protein-protein association [PDF]

, 2010
Conformational changes upon protein-protein association are the key element of the binding mechanism. The study presents a systematic large-scale analysis of such conformational changes in the side chains.
Kirys, Tatsiana, Ruvinsky, Anatoly M., Tuzikov, Alexander V., Vakser, Ilya A.   +3 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex

Cell Communication and Signaling, 2022
Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of voltage-gated ion channels, but a full picture of ...
Martyna Sochacka, Radoslaw Karelus, Lukasz Opalinski, Daniel Krowarsch, Martyna Biadun, Jacek Otlewski, Malgorzata Zakrzewska   +6 more
doaj   +1 more source

Sensitivity dependent model of protein-protein interaction networks

, 2008
The scale free structure p(k)~k^{-gamma} of protein-protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and find the key reason for the model to generate apparent scale free degree ...
Estojak J, Eugene I Shakhnovich, Jingshan Zhang, Wagner A   +3 more
core   +1 more source

Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions [PDF]

, 2015
Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a ...
Azzarito, Barnard, Barth, Berg, Bieging, Borner, Bruncko, Bullock, Burslem, Campbell, Cao, Cheloha, Chipuk, González-Bulnes, Grigoryev, Guichard, Harker, Hoe, Kazi, Kussie, Lao, Lao, Lee, Liu, Long, Mathew, Milroy, Moldoveanu, Moran, Nevola, Oh, Orner, Pan, Saraogi, Saraogi, Schuler, Schäfer, Scott, Shangary, Spiegel, Stumpf, Thornberry, Uhrinova, Vassilev, Vu, Wade, Wells, Yao, Yin, Yin, Zhang, Zhang   +51 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source