Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins [PDF]
, 2018 Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways.
Baglivo, I +18 more
core +2 more sources
Protein aggregation. Studies of larger aggregates of C-phycocyanin [PDF]
Biochemical Journal, 1968 Aggregates of phycocyanin sedimenting at 17s, 22s and 27s are demonstrated to constitute more than 40% of crude blue–green-algal extracts, pH6·0 and I0·1, and are retained in highly purified preparations. Sedimentation-velocity studies of the large aggregates as a function of pH are reported. Sucrose-density-gradient experiments performed as a function
J J, Lee, D S, Berns
openaire +2 more sources
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. [PDF]
, 2019 Tau aggregation is a hallmark feature in a subset of patients with frontotemporal dementia (FTD). Early and selective loss of von Economo neurons (VENs) and fork cells within the frontoinsular (FI) and anterior cingulate cortices (ACC) is observed in ...
Coppola, Giovanni +13 more
core +1 more source
Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. [PDF]
, 2020 BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic
Alexander-Floyd, J +6 more
core +1 more source
The aggregation of cytochrome C may be linked to its flexibility during refolding [PDF]
, 2016 Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with denaturant, a ...
A Basu +19 more
core +1 more source
Tau protein aggregation is associated with cellular senescence in the brain
Aging Cell, 2018 Tau protein accumulation is the most common pathology among degenerative brain diseases, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), traumatic brain injury (TBI), and over twenty others. Tau‐containing neurofibrillary tangle
N. Musi +6 more
semanticscholar +1 more source
Nanoparticles in relation to peptide and protein aggregation
International Journal of Nanomedicine, 2014 Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of
Zaman M +4 more
doaj
Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. [PDF]
PLoS Computational Biology, 2009 Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure.
Virginia Castillo, Salvador Ventura
doaj +1 more source
mAbs, 2021 Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature.
Salla Valtonen +5 more
doaj +1 more source
Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]
, 2017 Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K +17 more
core +2 more sources