Results 81 to 90 of about 436,505 (303)

Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. [PDF]

PLoS Computational Biology, 2009
Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure.
Virginia Castillo, Salvador Ventura
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Protein aggregation in E. coli : short term and long term effects of nutrient density. [PDF]

PLoS ONE, 2014
During exponential growth some cells of E. coli undergo senescence mediated by asymmetric segregation of damaged components, particularly protein aggregates. We showed previously that functional cell division asymmetry in E.
Ulfat I Baig, Bharati J Bhadbhade, Dincy Mariyam, Milind G Watve   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Protein Aggregation [PDF]

Protein Science, 2018
Baum, J, Raleigh, D
openaire   +4 more sources

Spatial control of irreversible protein aggregation

eLife, 2019
Liquid cellular compartments form in the cyto- or nucleoplasm and can regulate aberrant protein aggregation. Yet, the mechanisms by which these compartments affect protein aggregation remain unknown. Here, we combine kinetic theory of protein aggregation
Christoph Weber, Thomas Michaels, L Mahadevan   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells [PDF]

, 2019
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation.
Santaguida, Stefano, Wells, Jonathan N, Wells J. N., Santaguida S., Amon A., Wells, Jonathan N., Marsh, Joseph A., Vaites, Laura Pontano, Storchova, Zuzana, Harper, J Wade, Amon, Angelika, Brennan C. M., Harper, J. Wade, Brennan, Christopher M, Amon, Angelika B, Harper J. W., Paulo, Joao A, Marsh J. A., Paulo J. A., Vaites L. P., Marsh, Joseph A; id_orcid, Paulo, Joao A., Storchova Z.   +22 more
core   +1 more source

Protein aggregation in progressive myoclonus epilepsies and related syndromes [PDF]

Exploration of Neuroscience
For this review paper, data on protein misfolding and aggregation in progressive myoclonus epilepsies and some developmental encephalopathies are gathered.
Eva Žerovnik
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source