Results 91 to 100 of about 436,505 (303)
Some factors determining protein aggregation during ultrafiltration
, 1993 The factors contributing to protein aggregation in albumin ultrafiltration were investigated as a function of operation conditions. The nature of protein deposits was examined by electron microscopy.
Fane, A. G., Kim, K. J., Chen, V.
core +1 more source
Harmine Acts as an Indirect Inhibitor of Intracellular Protein Aggregation
, 2020 Protein aggregation and oxidative stress are two pathological hallmarks of a number of protein misfolding diseases, including Huntington’s disease (HD).
Swati Jain (569859) +3 more
core +1 more source
Molecular rotors as novel probes of protein aggregation [PDF]
, 2018 Molecular rotors are a class of fluorophores that display environmentally-sensitive photophysics. The fluorescence intensities and lifetimes of these molecules strongly depend upon the viscosity of their immediate surroundings, the surrounding ...
Kubankova, Marketa
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cadmium and arsenite are common environmental pollutants; considered highly toxic and pose a substantial threat to human health with millions of people worldwide being at risk of exposure.
Andersson, Stefanie
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Elucidating the effects of nucleic acid aptamers on protein aggregation [PDF]
, 2020 Protein aggregation is an important topic for human health and biotechnology, with consequences in areas ranging from neurodegenerative diseases to therapeutic protein production yields.
Tran, Claire
core
The role of glia in protein aggregation
Neurobiology of Disease, 2020 Protein aggregation diseases involve intracellular accumulation or extracellular deposition of certain protein species in neuronal or glial cells, leading to neurodegeneration and shortened lifespan. Prime examples include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), which are ...
Qingyun Li, Michael S. Haney
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Prediction of Protein Aggregation Propensity via Data-Driven Approaches
Protein aggregation occurs when misfolded or unfolded proteins physically bind together and can promote the development of various amyloid diseases. This study aimed to construct surrogate models for predicting protein aggregation via data-driven methods
Seungpyo Kang (14461252) +4 more
core +2 more sources