Results 91 to 100 of about 737,709 (296)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins [PDF]

, 2018
Significant advances in the understanding of the molecular determinants of fibrillogenesis can be expected from comparative studies of the aggregation propensities of proteins with highly homologous structures but different folding pathways.
Baglivo, I, Coletta, M, D'Abrosca, G, De Stefano, M, Fattorusso, R., Gianni, S, Isernia, C, Majewska, R, Malgieri, G, Milardi, D, Palmieri, M, Pedone, Em, Pedone, Pv, Pirone, L, Russo, L, Sciacca, Mfm, Sivo, V, Tatè, R, Toto, A   +18 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein aggregation in progressive myoclonus epilepsies and related syndromes [PDF]

Exploration of Neuroscience
For this review paper, data on protein misfolding and aggregation in progressive myoclonus epilepsies and some developmental encephalopathies are gathered.
Eva Žerovnik
doaj   +1 more source

Protein aggregation in E. coli : short term and long term effects of nutrient density. [PDF]

PLoS ONE, 2014
During exponential growth some cells of E. coli undergo senescence mediated by asymmetric segregation of damaged components, particularly protein aggregates. We showed previously that functional cell division asymmetry in E.
Ulfat I Baig, Bharati J Bhadbhade, Dincy Mariyam, Milind G Watve   +3 more
doaj   +1 more source

Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington\u27s disease model system [PDF]

, 2016
Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.
Denis, Clyde L., Wang, Xin, Xi, Wen
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enrichment and aggregation of topological motifs are independent organizational principles of integrated interaction networks

, 2011
Topological network motifs represent functional relationships within and between regulatory and protein-protein interaction networks. Enriched motifs often aggregate into self-contained units forming functional modules.
Anagha Joshi, Björklund, Brin, Bruno Nachtergaele, Csikász-Nagy, De Lathauwer, de Lichtenberg, Dobrin, Fiedler, Harbison, Hartwell, Huang, Kalir, Kashtan, Kashtan, Kellog, Kleinberg, Kraemer, Lee, Lee, Loch, Mazurie, McClellan, Mendenhall, Milo, Neely, Newman, Planta, Ptacek, Ravasz, Reguly, Shen-Orr, Solé, Solé, Spellman, Stark, Tan, Tom Michoel, Vázquez, Yeger-Lotem, Yeger-Lotem, Yosef, Yu, Yves Van de Peer, Zhang, Zhao   +45 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source