Results 191 to 200 of about 7,628,689 (242)

Protein aggregates caught stalling

Nature, 2018
Low-complexity protein aggregates are a hallmark of neurodegeneration. High-resolution snapshots of the structure of one such aggregate offer an unprecedented view of how these proteins disrupt crucial cellular functions. Low-complexity protein aggregates are a hallmark of neurodegeneration.
Laura, Pontano Vaites, J Wade, Harper
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Protein Misfolding and Aggregation

Biotechnology Progress, 2008
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: (1) the sharp rise in the number and volume of therapeutic proteins produced commercially and (2) the recognition of the central role of protein aggregates in degenerative diseases.
Regina M, Murphy, Brent S, Kendrick
openaire   +2 more sources

β-Amyloid Protein Aggregation

2007
The beta-amyloid peptide aggregates via a nucleation pathway where micellar aggregates propagate to form oligomers (protofibrils), which then polymerize into insoluble fibrils. This fibrillogenic process has been linked to the pathogenesis associated with Alzheimer's disease.
Marcus A, Etienne, Nadia J, Edwin, Jed P, Aucoin, Paul S, Russo, Robin L, McCarley, Robert P, Hammer   +5 more
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Protein aggregation - Mechanisms, detection, and control.

International journal of pharmaceutics, 2018
Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of the inherent and high aggregation tendency during various manufacturing processes ...
Wei Wang, C. Roberts
semanticscholar   +1 more source

Advances in the prediction of protein aggregation propensity.

Current Medicinal Chemistry, 2019
Protein aggregation into β-sheet-enriched insoluble assemblies is being found to be associated with an increasing number of debilitating human pathologies, such as Alzheimer's disease or type 2 diabetes, but also with premature aging.
I. Pallarès, S. Ventura
semanticscholar   +1 more source

DNAJ Proteins and Protein Aggregation Diseases

Current Topics in Medicinal Chemistry, 2013
Many neurodegenerative diseases are late onset diseases, associated with aggregation of proteins, implying that aged cells are more susceptible to proteotoxic stress. It is known that with aging, there is a decline in the functionality of chaperone networks and on the other hand, accumulation of damaged proteins occurs.
Vaishali, Kakkar, Louis C B, Prins, Harm H, Kampinga   +2 more
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Protein aggregation

International Journal of Biological Macromolecules, 2017
Ipsita, Roy, Boris I, Kurganov
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Physicochemical Principles of Protein Aggregation

2013
This chapter provides a theoretical framework on the quantitative description of protein aggregation. The reader is provided with an overview of the fundamental theory of linear and helical polymers, as well as an introduction on the parameters governing evolution of aggregates over time.
Bolognesi B., Tartaglia G. G.
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Protein aggregation: An overview

In order for an ordered protein to perform its specific function, it must have a specific molecular structure. Information about this structure is encoded in the protein's amino acid sequence. The unique functional state is achieved as a result of a specific process, known as protein folding. However, as a result of partial or complete unfolding of the
Bahareh, Dabirmanesh, Khosro, Khajeh, Vladimir N, Uversky   +2 more
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Protein Denaturation and Aggregation

Annals of the New York Academy of Sciences, 2006
Abstract: Protein aggregation is a prominent feature of many neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases, as well as spongiform encephalopathies and systemic amyloidoses. These diseases are sometimes called protein misfolding diseases, but the latter term begs the question of what is the “folded” state of ...
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