Results 211 to 220 of about 432,033 (262)

Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis. [PDF]

Bioorg Chem
Elmansy MF, Soares P, Dos Remedios JRD, Nowar R, Fox SG, Yu A, Klein WL, Morimoto RI, Silverman RB.   +8 more
europepmc   +1 more source

Massive experimental quantification allows interpretable deep learning of protein aggregation. [PDF]

Sci Adv
Thompson M, Martín M, Olmo TS, Rajesh C, Koo PK, Bolognesi B, Lehner B.   +6 more
europepmc   +1 more source

A Focus on the Link Between Metal Dyshomeostasis, Norepinephrine, and Protein Aggregation. [PDF]

Antioxidants (Basel)
Bacchella C, Capucciati A, Monzani E.
europepmc   +1 more source

Submolecular Resolution of β‑Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders. [PDF]

ACS Cent Sci
Wang R, Jian Z, Yang Y, Wang C, Yu L, Wang M, Wang C.   +6 more
europepmc   +1 more source

Dual mechanism of autophagy gene repression by PHF23 and therapeutic potential of its inhibition in protein aggregation disorders. [PDF]

Nucleic Acids Res
Choi SA, Kim J, Yu YS, Kim J, Kim SI, Bae H, Kwon J, Kim KI, Baek SH.   +8 more
europepmc   +1 more source

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Protein Aggregation

Clinical Chemistry and Laboratory Medicine, 2001
Protein aggregation occurs in vivo as a result of improper folding or misfolding. Diverse diseases arise from protein misfolding and are now grouped under the term "protein conformational diseases", including most of the neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, the prion encephalopathies and Huntington's disease, as
MERLINI, GIAMPAOLO, BELLOTTI, VITTORIO, ANDREOLA, ALESSIA, PALLADINI, GIOVANNI, Obici L, Casarini S, Perfetti V.   +6 more
openaire   +3 more sources

Protein aggregation and prionopathies

Pathologie Biologie, 2014
Prion protein and prion-like proteins share a number of characteristics. From the molecular point of view, they are constitutive proteins that aggregate following conformational changes into insoluble particles. These particles escape the cellular clearance machinery and amplify by recruiting the soluble for of their constituting proteins.
Renner, M, Melki, Ronald
openaire   +2 more sources

Mechanisms of Protein Aggregation

Current Pharmaceutical Biotechnology, 2009
Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
John S, Philo, Tsutomu, Arakawa
openaire   +2 more sources

Protein Misfolding and Aggregation

Biotechnology Progress, 2008
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: (1) the sharp rise in the number and volume of therapeutic proteins produced commercially and (2) the recognition of the central role of protein aggregates in degenerative diseases.
Regina M, Murphy, Brent S, Kendrick
openaire   +2 more sources