Results 81 to 90 of about 7,628,689 (242)

Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells

Frontiers in Chemistry, 2019
In general, neurodegenerative disorders have a great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules.
Anzar Abdul Mujeeb, Khan Farheen Badre Alam, Ansam Wadia Faid Alshameri, Fauzia Jamal, Saba Farheen, Mohd Kashif, Anees Ahmed, Irfan Ahmad Ghazi, Mohammad Owais   +8 more
doaj   +1 more source

The amyloid interactome: Exploring protein aggregation. [PDF]

PLoS ONE, 2017
Protein-protein interactions are the quintessence of physiological activities, but also participate in pathological conditions. Amyloid formation, an abnormal protein-protein interaction process, is a widespread phenomenon in divergent proteins and ...
Konstantina V Biza, Katerina C Nastou, Paraskevi L Tsiolaki, Chara V Mastrokalou, Stavros J Hamodrakas, Vassiliki A Iconomidou   +5 more
doaj   +1 more source

Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function [PDF]

, 2017
TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing.
Ayala, Yuna M, Bigio, Eileen H, Fey, Erin E, French, Rachel L, Knoverek, Catherine R, Li, Wen, Lin, Binyan, Reeb, Ashley N, Subramanian, Praveen   +8 more
core   +2 more sources

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

Genes & Development, 2019
In this study, Brennan et al. identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. They propose that proteotoxic stress is a universal feature of aneuploid cells and show that degradation and ...
C. Brennan, L. P. Vaites, J. Wells, S. Santaguida, J. Paulo, Z. Storchová, J. Harper, J. Marsh, A. Amon   +8 more
semanticscholar   +1 more source

RNA as the stone guest of protein aggregation

Nucleic Acids Research, 2020
The study of prions as infectious aggregates dates several decades. From its original formulation, the definition of a prion has progressively changed to the point that many aggregation-prone proteins are now considered bona fide prions.
A. Louka, E. Zacco, P. Temussi, G. Tartaglia, A. Pastore   +4 more
semanticscholar   +1 more source

Atomic force microscopy for single molecule characterisation of protein aggregation

Archives of Biochemistry and Biophysics, 2019
The development of atomic force microscopy (AFM) has opened up a wide range of novel opportunities in nanoscience and new modalities of observation in complex biological systems.
F. Ruggeri, Tomas Šneideris, M. Vendruscolo, T. Knowles   +3 more
semanticscholar   +1 more source

Cross-talk between redox signalling and protein aggregation

Biochemical Society Transactions, 2020
It is well established that both an increase in reactive oxygen species (ROS: i.e. O2•−, H2O2 and OH•), as well as protein aggregation, accompany ageing and proteinopathies such as Parkinson's and Alzheimer's disease.
Loes van Dam, T. Dansen
semanticscholar   +1 more source

Lipid-protein interaction induced domains: kinetics and conformational changes in multicomponent vesicles

, 2018
The spatio-temporal organization of proteins and the associated morphological changes in membranes are of importance in cell signaling. Several mechanisms that promote the aggregation of proteins at low cell surface concentrations have been investigated ...
Kumar, P. B. Sunil, Sreeja, K. K.
core   +1 more source

Statistical Mechanical Treatments of Protein Amyloid Formation [PDF]

, 2013
Protein aggregation is an important field of investigation because it is closely related to the problem of neurodegenerative diseases, to the development of biomaterials, and to the growth of cellular structures such as cyto-skeleton. Self-aggregation of
Schreck, John S., Yuan, Jian-Min
core   +3 more sources

Propagation of Protein Aggregation in Neurodegenerative Diseases.

Annual Review of Biochemistry, 2019
Most common neurodegenerative diseases feature deposition of protein amyloids and degeneration of brain networks. Amyloids are ordered protein assemblies that can act as templates for their own replication through monomer addition. Evidence suggests that
J. Vaquer-Alicea, M. Diamond
semanticscholar   +1 more source