Results 81 to 90 of about 737,165 (295)

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity [PDF]

, 2015
Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are ...
Andrade-Navarro, Miguel A., Bates, Gillian P., Boeddrich, Annett, Bounab, Yacine, Chaurasia, Gautam, Fournier, David, Friedrich, Ralf P., Futschik, Matthias E., Graham, Rona K., Haenig, Christian, Hayden, Michael R., Hesse, Franziska, Klockmeier, Konrad, Li, Shuang, Nicoletti, Cecilia, Priller, Josef, Riechers, Sean-Patrick, Russ, Jenny, Schnoegl, Sigrid, Sigrist, Stephan, Strempel, Nadine, Stroedicke, Martin, Wanker, Erich E., Wiglenda, Thomas, Yigit, Sargon   +24 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CPAD, Curated Protein Aggregation Database: A Repository of Manually Curated Experimental Data on Protein and Peptide Aggregation. [PDF]

PLoS ONE, 2016
Accurate distinction between peptide sequences that can form amyloid-fibrils or amorphous β-aggregates, identification of potential aggregation prone regions in proteins, and prediction of change in aggregation rate of a protein upon mutation(s) are ...
A Mary Thangakani, R Nagarajan, Sandeep Kumar, R Sakthivel, D Velmurugan, M Michael Gromiha   +5 more
doaj   +1 more source

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]

, 2019
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal, Hadrovic, Inesa, Klärner, Frank-Gerrit, Rebmann, Philipp, Schrader, Thomas   +4 more
core  

Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. [PDF]

, 2020
BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic
Alexander-Floyd, J, Entezari, A A, Gidalevitz, T, Haroon, S, Jaeger, C, Vermulst, M, Ying, M   +6 more
core   +1 more source

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation [PDF]

, 2011
Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP.
A Horvath, A Natalello, A Zhou, AG Murzin, AM Arutyunyan, AM Fernandez-Escamilla, Angel L. Pey, Angela M. Gronenborn, Anja Underhaug Gjerde, AP Kornev, Aurora Martinez, C Kim, CE Poteet-Smith, CI Bayly, Claudine Mayer, D Hamada, D Vigil, DA Case, DA Leon, DA Leon, DT Haynie, E Deu, EL Greene, F Chiti, G Soldi, H Azakami, H LeVine 3rd, H Rehmann, I Luque, IJ Byeon, IM Plaza del Pino, In-Ja L. Byeon, J Sancho, J Wang, J Wang, J Wu, JA Beavo, JA Carney, JM Canaves, JM Louis, JM Sanchez-Ruiz, JP Ryckaert, JS Richardson, KE Tang, Khanh K. Dao, KK Dao, Knut Teigen, L Holm, M Fandrich, M Fandrich, M Manno, M Mauro, M Thórólfsson, MA Andrade, MS Akhtar, N Ferguson, N Kannan, P Banky, R Aoki, R Das, R Day, R Kopperud, R Shrivastava, RW Carrell, SO Doskeland, SS Taylor, SS Taylor, Stein O. Døskeland, TJ Kamerzell, U Essmann, V Vetri, VJ Hilser, W Wong, WD Cornell, WL Jorgensen, WN Lanzilotta, Y Su   +76 more
core   +8 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Aggregation and conformational stability evaluation of myoglobin in the presence of ionic surfactant

Saudi Pharmaceutical Journal, 2018
Sodium lauroyl sarcosinate (SLS) is frequently used for the solubilization of inclusion bodies in vitro due to its structural similarity to lipid plasma membrane.
Mohammad A. Alsenaidy
doaj   +1 more source

Protein aggregation in E. coli : short term and long term effects of nutrient density. [PDF]

PLoS ONE, 2014
During exponential growth some cells of E. coli undergo senescence mediated by asymmetric segregation of damaged components, particularly protein aggregates. We showed previously that functional cell division asymmetry in E.
Ulfat I Baig, Bharati J Bhadbhade, Dincy Mariyam, Milind G Watve   +3 more
doaj   +1 more source

REACTIVITY OF CHLOROPHYLL a/b-PROTEINS AND MICELLAR TRITON X-100 COMPLEXES OF CHLOROPHYLLS a OR b WITH BOROHYDRIDE [PDF]

, 1989
The reaction of several plant chlorophyll-protein complexes with NaBH4 has been studied by absorption spectroscopy. In all the complexes studied, chlorophyll b is more reactive than Chi a, due to preferential reaction of its formyl substituent at C-7 ...
Arnon D. I., Beese D., Brody S. S., Brune D. C., Ford R. C., Holt A. S., Holten D., Michel H., Olson J. M., Omata T., Ryrie I. J., Scheer H., Scheer H., Schoch S., Siefermann-Harms D., Smith K. M.   +15 more
core   +1 more source