Results 91 to 100 of about 3,196,863 (318)

High-Mobility-Group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus Type 1 proviral promoter [PDF]

, 2000
HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces.
Henderson, A., Tremethick, D.J., Siddon, N., Reeves, R., Bunce, M.   +4 more
core   +1 more source

Computational and experimental antibody affinity and diagnostic accuracy quantification of SARS-CoV-2 SD2 major disulfide loop analog

Frontiers in Tropical Diseases
IntroductionSynthetic oligopeptides provide a rapid and cost-efficient approach to developing antibodies and diagnostics for emerging viral variants.MethodsThis study computationally and experimentally characterized a synthetic peptide analog of the SARS-
Brian Andrich L. Pollo, Glenmarie Angelica S. Perias, Riziel Hannah B. Aguimatang, Ayra Patrice N. Espiritu, Danica S. Ching, Maria Isabel C. Idolor, Ruby Anne N. King, Fresthel Monica M. Climacosa, Salvador Eugenio C. Caoili   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy [PDF]

, 2006
Ribosomal proteins are assumed to stabilize specific RNA structures and promote compact folding of the large rRNA. The conformational dynamics of the protein between the bound and unbound state play an important role in the binding process.
Wöhnert, Jens, Hendrik R. A. Jonker, Harald Schwalbe, Ilin, Serge, S. Kaspar Grimm, Grimm, Steffen Kaspar, Jens Wöhnert, Jonker, Hendrik R. A., Schwalbe, Harald (Prof. Dr.), Serge Ilin   +9 more
core   +1 more source

Protein koji vezuje manozu - činilac urođenog imunskog odgovora [PDF]

Vojnosanitetski Pregled, 2003
Gruden-Movsesijan Alisa A.
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Time-Resolved Fluorescence Investigation of the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein: Influence of the Binding of Nucleic Acids [PDF]

, 1999
Depending on the HIV-1 isolate, MN or BH10, the nucleocapsid protein, NCp7, corresponds to a 55- or 71-amino acid length product, respectively. The MN NCp7 contains a single Trp residue at position 37 in the distal zinc finger motif, and the BH10 NCp7 ...
Piemont, Etienne, Constance Vuilleumier, Etienne Piémont, Gerard, Dominique, Roques, Bernard P., Ababou, Abdessamad, Mely, Yves, Yves Mély, Bombarda, Elisa, Dominique Gérard, Bernard P. Roques, Abdessamad Ababou, Vuilleumier, Constance, Elisa Bombarda   +13 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis [PDF]

, 2012
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide ...
Summers, Emma Louise
core  

Sequence specificity of single-stranded DNA-binding proteins:a novel DNA microarray approach [PDF]

, 2007
We have developed a novel DNA microarray-based approach for identification of the sequence-specificity of single-stranded nucleic-acid-binding proteins (SNABPs).
Estibeiro, Peter, Heinemann, U., Wear, M.A., Max, K.E., Morgan, Hugh P, Max, Klaas E A, Sadler, P.J., Morgan, H.P., Walkinshaw, M.D., Heinemann, Udo, Walkinshaw, Malcolm D, Wear, Martin A, Gallagher, Maurice P, Cubeddu, L., Sadler, Peter J, Estibeiro, P., Gallagher, M.P., Cubeddu, Liza   +17 more
core   +1 more source