Results 81 to 90 of about 3,196,863 (318)

Dynamics and thermodynamics of protein-ligand interactions [PDF]

, 2012
Complex networks of protein-ligand interactions underpin cellular function and communication. Disease can arise from disruption of these networks through the alteration of protein-ligand interaction affinities, for example by protein mutation or ligand ...
Malham, Richard William
core  

Visualization of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets [PDF]

, 2012
Background: Protein structures provide a valuable resource for rational drug design. For a protein with no known ligand, computational tools can predict surface pockets that are of suitable size and shape to accommodate a complementary small-molecule ...
Povia, Alice, Nobeli, Irene, Paul Ashford, Nobeli, Irilenia, Moss, David S., Siew K Yeap, Alex, A., Alexander Alex, Mark A Williams, Irene Nobeli, Ashford Paul, Alice Povia, Ashford, Paul, David S Moss, Yeap Siew K, Alex Alexander, Povia Alice, Williams Mark A, Williams, Mark A., Nobeli Irene, Moss David S, Yeap, S.K.   +21 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]

, 2006
The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias, Ptushkina, Marina, Wagner, Gerhard, McCarthy, John E G, Moerke, Nathan, Oku, Yuko, McCarthy, John E. G., Mccarthy, John, Gross, John D.   +8 more
core   +1 more source

Editorial: Women in pharmacology of infectious diseases: 2021

Frontiers in Pharmacology, 2022
Elena K. Schneider-Futschik, Isabel Spriet, Hong Zhou   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Protein-ligand binding affinities from large-scale quantum mechanical simulations [PDF]

, 2012
The accurate prediction of protein-drug binding affinities is a major aim of computational drug optimisation and development. A quantitative measure of binding affinity is provided by the free energy of binding, and such calculations typically require ...
Fox, Stephen J, Fox, Stephen J.
core  

Toward Rational Design of Ion-Exchange Nanofiber Membranes: Meso-Scale Computational Approaches

Membranes
This review highlights the growing relevance of ion-exchange nanofibrous membranes (IEX-NFMs) in membrane chromatography (MC) for protein purification, emphasising their structural advantages such as high porosity, tunable surface functionality, and low ...
Inci Boztepe, Shuaifei Zhao, Xing Yang, Lingxue Kong   +3 more
doaj   +1 more source

UL16 binding proteins

Immunobiology, 2004
According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B in human and Rae1 in mice, which is
Wei, Cao, Wei, He
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source