Results 141 to 150 of about 10,846,120 (403)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Editorial: Women in pharmacology of infectious diseases: 2021

Frontiers in Pharmacology, 2022
Elena K. Schneider-Futschik, Isabel Spriet, Hong Zhou   +2 more
doaj   +1 more source

STUDIES ON THE METABOLISM OF PLASMA PROTEINS IN THE NEPHROTIC SYNDROME. I. ALBUMIN, γ-GLOBULIN AND IRON-BINDING GLOBULIN 1 [PDF]

, 1956
David Gitlin, Charles A. Janeway, Lee E. Farr   +2 more
openalex   +1 more source

A Designed Conformational Shift To Control Protein Binding Specificity**

Angewandte Chemie, 2014
In a conformational selection scenario, manipulating the populations of binding-competent states should be expected to affect protein binding. We demonstrate how in silico designed point mutations within the core of ubiquitin, remote from the binding ...
Servaas Michielssens, J. Peters, David Ban, Supriya Pratihar, Daniel Seeliger, Monika Sharma, Karin Giller, T. M. Sabo, S. Becker, Donghan Lee, C. Griesinger, B. L. de Groot   +11 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Successful prediction of LC8 binding to intrinsically disordered proteins sheds light on AlphaFold’s black box

Frontiers in Molecular Biosciences
IntroductionLC8 is a hub protein involved in many processes from tumor suppression and cell cycle regulation to neurotransmission and viral infection.
Douglas R. Walker, Gretchen Fujimura, Juan M. Vanegas, Elisar J. Barbar   +3 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

Nucleic Acids Research, 2017
N 6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA (mRNA), and affects almost every stage of the mRNA life cycle. The YTH-domain proteins can specifically recognize m6A modification to control mRNA maturation,
Nian Liu, K. I. Zhou, M. Parisien, Qing Dai, L. Diatchenko, T. Pan   +5 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Protein koji vezuje manozu - činilac urođenog imunskog odgovora [PDF]

Vojnosanitetski Pregled, 2003
Gruden-Movsesijan Alisa A.
doaj   +1 more source