Results 11 to 20 of about 2,760,628 (268)
PEDOT-Polyamine-Based Organic Electrochemical Transistors for Monitoring Protein Binding
Biosensors, 2023 The fabrication of efficient organic electrochemical transistors (OECTs)-based biosensors requires the design of biocompatible interfaces for the immobilization of biorecognition elements, as well as the development of robust channel materials to enable ...
Marjorie Montero-Jimenez +5 more
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Applied Sciences, 2021 Platinum (Pt) antineoplastic agents remain indispensable for the treatment of oncological disease. Pt-based drugs are mainly used in the therapy of ovarian cancer and non-small-cell lung carcinoma.
Elena Fedoros +4 more
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An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans +8 more
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Largazole Pharmacokinetics in Rats by LC-MS/MS
Marine Drugs, 2014 A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu +9 more
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mBio, 2017 The type 3 secretion system (T3SS) is essential for bacterial virulence through delivering effector proteins directly into the host cytosol. Here, we identified an alternative delivery mechanism of virulence factors mediated by the T3SS, which consists ...
Farid Tejeda-Dominguez +3 more
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Osteoarthritis and Cartilage, 2001 The connective tissues are crucial for multicellular organisms, playing many diverse roles both structurally and mechanically as well as providing a protective function. They make up the frame of the mammalian body and add strength and elasticity, while their protective function is important both on the outside of the body and inside, where they ...
Svensson, L. +2 more
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A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA
Clinical, Cosmetic and Investigational Dermatology, 2023 David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide, Amy D Brideau-Andersen Allergan Aesthetics, an AbbVie Company, Irvine, CA, USACorrespondence: David C Rupp, Allergan Aesthetics, an AbbVie Company, 2525 Dupont
Rupp DC +6 more
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Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent
Marine Drugs, 2010 Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold,
Ruiwen Zhang +11 more
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Pharmaceutics, 2022 Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov +10 more
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A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
Biomolecules, 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy +2 more
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