Results 11 to 20 of about 4,243,838 (306)

Protein-protein binding supersites.

PLoS Computational Biology, 2019
The lack of a deep understanding of how proteins interact remains an important roadblock in advancing efforts to identify binding partners and uncover the corresponding regulatory mechanisms of the functions they mediate.
Raji Viswanathan, Eduardo Fajardo, Gabriel Steinberg, Matthew Haller, Andras Fiser   +4 more
doaj   +4 more sources

An Overview of the Protein Binding of Cephalosporins in Human Body Fluids: A Systematic Review

Frontiers in Pharmacology, 2022
Introduction: Protein binding can diminish the pharmacological effect of beta-lactam antibiotics. Only the free fraction has an antibacterial effect. The aim of this systematic literature review was to give an overview of the current knowledge of protein
C. Jongmans, A. E. Muller, A. E. Muller, P. Van Den Broek, B. De Melo Cruz De Almeida, C. Van Den Berg, J. Van Oldenrijk, P. K. Bos, B. C. P. Koch   +8 more
doaj   +1 more source

Largazole Pharmacokinetics in Rats by LC-MS/MS

Marine Drugs, 2014
A highly sensitive and specific LC-MS/MS method for the quantitation of largazole thiol, the active species of the marine-derived preclinical histone deacetylase inhibitor, largazole (prodrug), was developed and validated.
Mingming Yu, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi S. P. Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, Hendrik Luesch   +9 more
doaj   +1 more source

PocketPicker: analysis of ligand binding-sites with shape descriptors [PDF]

, 2007
Background Identification and evaluation of surface binding-pockets and occluded cavities are initial steps in protein structure-based drug design.
Weisel, Martin, Proschak, Ewgenij, Schneider, Gisbert (Prof. Dr.)   +2 more
core   +2 more sources

Disposition of Federally Owned Surpluses [PDF]

, 1944
PDZ domains are scaffolding modules in protein-protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of protein ligands. A conserved carboxylate-binding
A Bach, A Bach, A Bach, BA Appleton, BH Chang, BJ Hillier, BZ Harris, CN Chi, CN Chi, CN Chi, DA Doyle, E Chapman, E Kim, E Kim, ET Powers, FI Valiyaveetil, G Hultqvist, GM Elias, GS Beligere, H Remaut, H Tochio, H Tochio, HJ Lee, J Schultz, J Schultz, JA Wells, JF Amacher, JNN Eildal, JT Andreasen, JT Koh, KK Dev, KS Bateman, L Funke, M Aarts, M Sheng, M Vila-Perelló, MA Stiffler, MD Hill, MR Arkin, N Calosci, NX Wang, OA Karlsson, R Tonikian, RN McLaughlin Jr., S Deechongkit, S Seedorff, SH Gee, TW Muir, W Feng, Y Zhang, Z Songyang   +50 more
core   +2 more sources

A Novel Mechanism for Protein Delivery by the Type 3 Secretion System for Extracellularly Secreted Proteins

mBio, 2017
The type 3 secretion system (T3SS) is essential for bacterial virulence through delivering effector proteins directly into the host cytosol. Here, we identified an alternative delivery mechanism of virulence factors mediated by the T3SS, which consists ...
Farid Tejeda-Dominguez, Jazmin Huerta-Cantillo, Lucia Chavez-Dueñas, Fernando Navarro-Garcia   +3 more
doaj   +1 more source

The structure of an LIM-only protein 4 (LMO4) and deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 [PDF]

, 2016
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1 ...
Cubeddu, Liza, Joseph, Soumya, Kwan, Ann H., Mackay, Joel P., Matthews, Jacqueline M., Stokes, Philippa H.   +5 more
core   +1 more source

A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA

Clinical, Cosmetic and Investigational Dermatology, 2023
David C Rupp, David Canty, Catherine Rhéaume, Birgitte Sondergaard, Celina Niño, Ron S Broide, Amy D Brideau-Andersen Allergan Aesthetics, an AbbVie Company, Irvine, CA, USACorrespondence: David C Rupp, Allergan Aesthetics, an AbbVie Company, 2525 Dupont
Rupp DC, Canty D, Rhéaume C, Sondergaard B, Niño C, Broide RS, Brideau-Andersen AD   +6 more
doaj  

Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

Marine Drugs, 2010
Marine natural products and their synthetic derivatives represent a major source of novel candidate anti-cancer compounds. We have recently tested the anti-cancer activity of more than forty novel compounds based on an iminoquinone makaluvamine scaffold,
Ruiwen Zhang, Wei Wang, Sadanandan E. Velu, Xinyi Yang, Charnell I. Sommers, Elizabeth R. Rayburn, Xu Zhang, Evrim Gurpinar, Hongxia Xu, Xiangrong Zhang, Scharri J. Ezell, Haibo Li   +11 more
doaj   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source