Pharmaceutics, 2022 Two chemical motifs of interest for medicinal chemistry, silatrane as 1-(3-aminopropyl) silatrane (SIL M), and nitro group attached in position 5 to salicylaldehyde, are coupled in a new structure, 1-(3-{[(2-hydroxy-5-nitrophenyl)methylidene]amino}propyl)
Mirela-Fernanda Zaltariov +10 more
doaj +1 more source
A Kinetic Transition Network Model Reveals the Diversity of Protein Dimer Formation Mechanisms
Biomolecules, 2023 Protein homodimers have been classified as three-state or two-state dimers depending on whether a folded monomer forms before association, but the details of the folding–binding mechanisms are poorly understood.
Dániel Györffy +2 more
doaj +1 more source
The Cell Density Factor CMF Regulates the Chemoattractant Receptor cAR1 in Dictyostelium [PDF]
, 1996 Starving Dictyostelium cells aggregate by chemotaxis to cAMP when a secreted protein called conditioned medium factor (CMF) reaches a threshold concentration.
Bishop, John D., +2 more
core +4 more sources
Osteoarthritis and Cartilage, 2001 The connective tissues are crucial for multicellular organisms, playing many diverse roles both structurally and mechanically as well as providing a protective function. They make up the frame of the mammalian body and add strength and elasticity, while their protective function is important both on the outside of the body and inside, where they ...
Svensson, L. +2 more
openaire +2 more sources
Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation [PDF]
, 2019 Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was ...
Egyed, Orsolya +6 more
core +4 more sources
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source
Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing
Pharmaceuticals, 2019 Peptide hormone hepcidin regulates systemic iron metabolism and has been described to be partially bound to α2-macroglobulin and albumin in blood. However, the reported degree of hepcidin protein binding varies between <3% and ≈89%.
Laura E. Diepeveen +8 more
doaj +1 more source
Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]
, 2013 Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg +57 more
core +1 more source
Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology
Frontiers in Medicine, 2021 Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial
Lionel Sebbag +5 more
doaj +1 more source
Real-time assembly of ribonucleoprotein complexes on nascent RNA transcripts. [PDF]
, 2018 Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available.
Duss, Olivier +5 more
core +2 more sources