Results 201 to 210 of about 2,760,628 (268)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Evaluation of teicoplanin protein-binding variability and clinical utility of its free serum concentration measurement. [PDF]

Sci Rep
Inno Y, Taogoshi T, Matsumoto A, Yokooji T, Matsuo H.   +4 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Multifunctional N-substituted 2-pyridylbenzothiazole derivatives: singlet oxygen generation, protein binding, and photoactivated anticancer and antibacterial activities. [PDF]

RSC Adv
Mohamed HA, Abdel-Shafi AA, Miyatake H, El-Khouly ME, Nassrallah AA.   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

VN-EGNN: E(3)- and SE(3)-Equivariant Graph Neural Networks with Virtual Nodes Enhance Protein Binding Site Identification. [PDF]

J Cheminform
Sestak F, Schneckenreiter L, Brandstetter J, Hochreiter S, Mayr A, Klambauer G.   +5 more
europepmc   +1 more source

Automatic Explanation of Protein-Protein Binding Mechanism: A Preliminary Study. [PDF]

Comput Struct Bioinform (2024)
Tam JZ, Liu Y, Jain DS, Armstrong G, Chen BY.   +4 more
europepmc   +1 more source

Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion. [PDF]

RNA
Falese JP, McFadden EJ, D'Inzeo CA, Hargrove AE.   +3 more
europepmc   +1 more source

Protein Binding Site Representation in Latent Space. [PDF]

Mol Inform
Lohmann F, Allenspach S, Atz K, Schiebroek CCG, Hiss JA, Schneider G.   +5 more
europepmc   +1 more source