Results 281 to 290 of about 4,419,405 (356)

The role of LRRC15-SCG5 in ECM protein binding as a prognostic signature for urothelial carcinoma. [PDF]

Am J Cancer Res
Dong SW, Chen CH, Tzou KY, Hu SW, Wu CC, Li CH.   +5 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Characterization of nuclease stability and poly(A)-binding protein binding activity of chemically modified poly(A) tail for <i>in vivo</i> applications. [PDF]

RSC Chem Biol
Hashimoto A, Kunitomo Y, Kikuchi I, Yamada H, Kobayashi K, Soshiroda K, Aman H, Kimura Y, Yamamoto J, Shiraishi Y, Uchida S, Abe H, Iwai H.   +12 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

N-Terminal Protein Binding and Disorder-to-Order Transition by a Synthetic Receptor. [PDF]

Biochemistry
Mockler NM, Ramberg KO, Flood RJ, Crowley PB.   +3 more
europepmc   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Inferring differential protein binding from time-series chromatin accessibility data. [PDF]

Bioinform Adv
Mitra S, Hartemink AJ.
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

RMDNet: RNA-aware dung beetle optimization-based multi-branch integration network for RNA-protein binding sites prediction. [PDF]

BMC Bioinformatics
Zhang J, Peng Y, Cui F, Zhang Z, Yan S, Zhang Q.   +5 more
europepmc   +1 more source