Results 51 to 60 of about 4,079,288 (357)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

CircGLIS3 Promotes High-Grade Glioma Invasion via Modulating Ezrin Phosphorylation

Frontiers in Cell and Developmental Biology, 2021
High-grade glioma is highly invasive and malignant, resistant to combined therapies, and easy to relapse. A better understanding of circular RNA (circRNA) biological function in high-grade glioma might contribute to the therapeutic efficacy.
Yan Li, Jiansheng Chen, Jiansheng Chen, Zetao Chen, Xiangdong Xu, Jun Weng, Yuxuan Zhang, Yunzhao Mo, Yang Liu, Jihui Wang, Yiquan Ke   +10 more
doaj   +1 more source

Gene silencing and large-scale domain structure of the E. coli genome

, 2012
The H-NS chromosome-organizing protein in E. coli can stabilize genomic DNA loops, and form oligomeric structures connected to repression of gene expression.
Lagomarsino, Marco Cosentino, Sclavi, Bianca, Zarei, Mina   +2 more
core   +2 more sources

Pre-hybridisation: an efficient way of suppressing endogenous biotin-binding activity inherent to biotin–streptavidin detection system [PDF]

, 2014
Endogenous biotin or biotinylated protein binding activity is a major drawback to biotin-avidin/streptavidin detection system. The avidin/streptavidin conjugate used to detect the complex of the biotinylated secondary antibody and the primary antibody ...
Andrew Thompsett, Banks, Bayer, Chandler, Chandler, Dakshinamurti, Emma Spikings, Haneji, Lifespan Biosciences Inc., Lombard, Moss, Praul, Raju Ahmed, Shaobo Zhou, Sheffield, Sigma-Aldrich, Taniguchi, Thermo Scientific, Tiantian Zhang, Vaitaitis, Wood, Wood, Yu   +22 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Molecular principles underlying dual RNA specificity in the Drosophila SNF protein [PDF]

, 2018
The first RNA recognition motif of the Drosophila SNF protein is an example of an RNA binding protein with multi-specificity. It binds different RNA hairpin loops in spliceosomal U1 or U2 small nuclear RNAs, and only in the latter case requires the ...
DeKoster, Gregory T, Hall, Kathleen B, Holton, Nicole, Wahl, Markus C, Weber, Gert   +4 more
core   +3 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Identifying Interaction Sites in "Recalcitrant" Proteins: Predicted Protein and Rna Binding Sites in Rev Proteins of Hiv-1 and Eiav Agree with Experimental Data [PDF]

, 2005
Protein-protein and protein nucleic acid interactions are vitally important for a wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses.
Carpenter, Susan, Dobbs, Drena, Dobbs, Drena, Honavar, Vasant, Jernigan, Robert, Jernigan, Robert, Lee, Jae-Hyung, Terribilini, Michael, Yan, Changhui   +8 more
core   +3 more sources

Capillarity Theory for the Fly-Casting Mechanism

, 2010
Biomolecular folding and function are often coupled. During molecular recognition events, one of the binding partners may transiently or partially unfold, allowing more rapid access to a binding site.
Chavez, Clementi, Clementi, Dunker, Dyson, E. Trizac, Finkelstein, Huang, Huang, Kubelka, Levy, Levy, Levy, Miyashita, Onuchic, Onuchic, P. G. Wolynes, Tompa, To  th-Petro  czy, Whitford, Wolynes, Wright, Wright, Y. Levy, Yang   +24 more
core   +2 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source