Results 241 to 250 of about 807,043 (313)

Signaling Bias as a Framework for Therapeutically Relevant Orthosteric Agonists: The β₂ Adrenergic Receptor Paradigm. [PDF]

Biochemistry
Georgiou K, Kolocouris A.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Introducing Experimental Design Concepts Improves Biochemistry Undergraduates' Experimental Laboratory Competence and Confidence. [PDF]

Biochem Mol Biol Educ
Tivendale ND, Van Dreumel A, Arthur PG.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Structural Polymorphs of Self-Assembled Brome Mosaic Virus Capsid Protein. [PDF]

J Phys Chem B
Harpell N, Duran-Meza AL, Elmer H, Knobler CM, Rodriguez JA, Gelbart WM.   +5 more
europepmc   +1 more source

<i>Hydroxamate formation in the lipopeptide containing siderophore</i> taiwachelin. [PDF]

Biochem Biophys Rep
Gringer AJ, Agwaza KP, Da Fonseca I, Sobrado P.   +3 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

A toxic STING-SAMHD1 axis drives replication stress in progeria and cancer cells. [PDF]

Nucleic Acids Res
Teodoro-Castro B, de Faria RC, Shashkova EV, Malique A, Adolph MB, Silva LND, Gonzalo S.   +6 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Dysregulated serum levels of human tissue kallikreins, hK7 and hK10, as potential biomarkers of asthma. [PDF]

Biochem Biophys Rep
Ejaz S, Nasim FU, Abdullah I, Ahmad S, Ashraf M.   +4 more
europepmc   +1 more source