Results 91 to 100 of about 526,449 (257)

Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women's breast tissue. [PDF]

Sci Rep, 2023
Hajirahimkhan A, Howell C, Bartom ET, Dong H, Lantvit DD, Xuei X, Chen SN, Pauli GF, Bolton JL, Clare SE, Khan SA, Dietz BM.   +11 more
europepmc   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis. [PDF]

Nucleic Acids Res, 2023
Sivakumar K, Venkadasamy VL, Amudhan G, Ann KJ, Goud GK, Nayani K, Gogoi J, Kuncha SK, Mainkar PS, Kruparani SP, Sankaranarayanan R.   +10 more
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Pathway and protein engineering for biosynthesis

Synthetic and Systems Biotechnology, 2022
Yongjin Zhou, Martin Grininger, Hal Alper   +2 more
doaj   +1 more source

NECAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research
The N-terminal EF-hand calcium-binding proteins 1–3 (NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal ...
Diones Bueno, Michael K.E. Schäfer, Sudena Wang, Michael J. Schmeisser, Axel Methner   +4 more
doaj   +1 more source

Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer. [PDF]

Biochem Pharmacol, 2023
Wei N, Burnett J, Crocker DL, Huang Y, Li S, Wipf P, Chu E, Schmitz JC.   +7 more
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Coordinated improvement of maize grain yield and protein quality by the ZmMADS8-ZmMADS47-O2 module and a G protein gamma subunit

Crop Journal
Improving protein quality and grain yield traits coordinately is an important goal for crop breeding. To date, many protein-quality or grain-yield regulation genes have been identified.
Yunfu Li, Qiang Ning, Ran Zhao, Dan Liu, Nan Li, Qing Xiong, Qin Sun, Yanfang Du, Ruijie Mao, Jimin Zhan, Zuxin Zhang, Lei Liu   +11 more
doaj   +1 more source

SMAD4 Loss Induces c-MYC-Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis. [PDF]

Cancer Res, 2022
Loevenich LP, Tschurtschenthaler M, Rokavec M, Silva MG, Jesinghaus M, Kirchner T, Klauschen F, Saur D, Neumann J, Hermeking H, Jung P.   +10 more
europepmc   +1 more source