Results 91 to 100 of about 3,693,345 (304)

Study on differential expression of 1-aminocyclopropane-1-carboxylic acid oxidase genes in table grape cv. Thompson Seedless [PDF]

, 2013
As a consequence of the non-climacteric status of grapes (Vitis vinifera), ethylene biosynthesis and signal transduction have scarcely been studied in this fruit.
González-Agüero, Mauricio, Defilippi, Bruno G., Chervin, Christian, Gudenschwager, Orianne, Munoz-Robredo, Pablo, Campos-Vargas, Reinaldo   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genome sequence of the pathogenic intestinal spirochete Brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine [PDF]

, 2009
Brachyspira hyodysenteriae is an anaerobic intestinal spirochete that colonizes the large intestine of pigs and causes swine dysentery, a disease of significant economic importance. The genome sequence of B.
Motro Yair, Ryan, K., Karon Ryan, Wanchanthuek Phatthanaphong, Hunter, A., Shaban, B., David J. Hampson, Barrero Roberto, Wanchanthuek, P, Nyree D. Phillips, Barrero, R., David S. Dunn, Barrero, R, Matthew I Bellgard, Moolhuijzen, Paula, Dunn David S., David S Dunn, Moolhuijzen, P., Motro, Y, Matthew I. Bellgard, La Tom, Phillips Nyree D., Hampson, D., Schibeci David, Hunter Adam, Nyree D Phillips, Shaban, B, Shaban Babak, Ryan, K, Albertyn, Z., Yair Motro, Ryan Karon, Albertyn, Z, Paula Moolhuijzen, Phillips, N., David Schibeci, Albertyn Zayed, Dunn, DS, Hampson, DJ, Babak Shaban, Motro, Y., Bellgard Matthew I., Hunter, A, Phillips, N.D., Schibeci, D, Moolhuijzen, P, Dunn, D.S., Tom La, Hampson David J., Hampson, D.J., Adam Hunter, Bellgard, MI, Roberto Barrero, Zayed Albertyn, Dunn, D., La, T, Bellgard, M., Moolhuijzen Paula, David J Hampson, Wanchanthuek, P., Phatthanaphong Wanchanthuek, La, T., Phillips, ND, Schibeci, D.   +63 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differential nitrate accumulation, nitrate reduction, nitrate reductase activity, protein production and carbohydrate biosynthesis in response to potassium and sodium nitrate [PDF]

, 2011
For most of the cultivated crops, nitrate is the major source of nitrogen. Most steps in the nitrate assimilatory pathway are nitrate inducible. In this study, Cucurbita pepo were grown in washed sand per pot at three potassium and sodium nitrate ...
Kavoosi, G, Balotf, S
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum [PDF]

, 2012
Heider S, Peters-Wendisch P, Wendisch VF. Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum. BMC Microbiology. 2012;12(1): 198.Background Corynebacterium glutamicum contains the glycosylated C50 carotenoid decaprenoxanthin as ...
Sabine A E Heider, Wendisch, Volker F. ; https://orcid.org/, Volker F Wendisch, Petra Peters-Wendisch, Peters-Wendisch, Petra, Heider, Sabine   +5 more
core   +1 more source

RNA-seq analysis of Brachypodium distachyon responses to Barley stripe mosaic virus infection

Crop Journal, 2017
Barley stripe mosaic virus (BSMV) is the type member of the genus Hordeivirus. Brachypodium distachyon line Bd3-1 shows resistance to the BSMV ND18 strain, but is susceptible to an ND18 double mutant (β NDTGB1R390K, T392K) in which lysine is substituted ...
Guoxin Wang, Ling Wang, Yu Cui, Meihua Yu, Chen Dang, Hao Wang, Xuejiao Jin, Lijie Yan, Qiuhong Wu, Dawei Li, Zhiyong Liu   +10 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transcriptome Remodeling and Adaptive Preservation of Muscle Protein Content in Hibernating Black Bears

Ecology and Evolution
Hibernation is an energy‐saving adaptation associated with physical inactivity. In contrast to most mammals, hibernating bears demonstrate limited loss of muscle mass and protein content over the prolonged periods of immobility and fasting during winter.
Vadim B. Fedorov, Arthur Garreau, Øivind Tøien, Brian M. Barnes, Anna V. Goropashnaya   +4 more
doaj   +1 more source