Results 101 to 110 of about 22,165,413 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

PROTEIN C DEFICIENCY PRESENTING AS CEREBRAL VENOUS SINUS THROMBOSIS. A CASE REPORT

Pakistan Armed Forces Medical Journal, 2020
Congenital protein C deficiency carries a high risk of venous1 and rarely arterial2 thrombosis and usually manifests as recurrent deep vein thrombosis or pulmonary embolism in young people.
Abdul Hameed Siddique, Zafar Ul Islam, Waseem Raja   +2 more
doaj   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Long-term Subcutaneous Protein C Replacement in Neonatal Severe Protein C Deficiency

, 2011
We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation.
Paul P. T. Brons, Mathijs Binkhorst, Ellen H. M. de Kort, Sabine L. A. G. Vrancken, Marcel P. J. M. Cuppen, Arno F. J. van Heijst   +5 more
core   +1 more source

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families [PDF]

, 2010
Isolated complex I deficiency is the most frequently observed oxidative phosphorylation defect in children with mitochondrial disease, leading to a diverse range of clinical presentations, including Leigh syndrome.
Mazhor Al-Dosary, Worgan, L, Jones, S, Robert W. Taylor, Lisa Worgan, Saretzki, G, Mansour, S, Sahar Mansour, Michael Clarke, David R. Thorburn, Robert McFarland, Thorburn, DR, Vanessa E. Hogan, Emma L. Blakely, Al-Dosary, M, Simon Jones, Hogan, VE, Devlin, AM, Langping He, Tuppen, HAL, Gabriele Saretzki, Alston, CL, Blakely, EL, Morris, AA, Charlotte L. Alston, Taylor, RW, Tuppen, HA, Chrzanowska-Lightowlers, ZMA, Zofia M. A. Chrzanowska-Lightowlers, Andrew A. Morris, Chrzanowska-Lightowlers, ZM, Clarke, M, Anita M. Devlin, Helen A. L. Tuppen, He, L, McFarland, R   +35 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Persistent fetal vasculature and severe protein C deficiency

, 2010
Persistent fetal vasculature (PFV) is most often a condition of unknown cause. It represents persisting elements of fetal ocular vessels including the hyaloid arterial network.
Douglas, A.G.L., Temple, I.K., Foulds, N.C., Nagra, A., N.C. Foulds, I.K. Temple, Morgan, M., M. Morgan, P. Hodgkins, A. Nagra, H. Rafferty, Rafferty, H., Hodgkins, P., A.G.L. Douglas   +13 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Frequency of Heterozygous Protein C Deficiency and Heterozygous Protein S Deficiency in Both Normal and Cerebral Thrombotic Conditions [PDF]

Protein C and protein S activities were assayed in 508 healthy subjects and in 121 patients with cerebral thrombosis, and the frequencies of the congenital deficiencies of these physiological anticoagulant proteins were examined. In the healthy subjects,
Endo, Takeshi, Tamura, Kohji, Kobayashi, Isao, Kurihara, Atsushi, 53430, 53433, Ozawa, Hideyuki, 53434, 53431, Yazaki, Akihiko, 53432, Amemiya, Norihiko, 53437, Kume, Shoji, 53435, 53436, Hamaoka, Satomi, 53428, Mizoe, Asako, 53429   +19 more
core   +1 more source