Results 1 to 10 of about 1,173 (113)

Protein S deficiency

Haematologica, 2008
In 1977, three years after the discovery of the γ-carboxy glutamic acid,[1][1] Richard DiScipio reported on the identification of a new vitamin K-dependent protein which was named protein S.[2][2] Three years later, Frederick Walker reported that bovine protein S functioned as a cofactor ...
Armando D’Angelo, Silvana Viganò D’Angelo   +1 more
doaj   +4 more sources

Deep Vein Thrombosis in Protein S Deficiency

Journal of Nepal Medical Association, 2010
Protein S is a vitamin K-dependent anticoagulant protein. It functions as a cofactor of activated protein C to inactivate activated factor V (FVa) and activated factor VIII (FVIIIa). Its deficiency is a rare condition and can lead to deep vein thrombosis,
A Joshi, J P Jaiswal
doaj   +4 more sources

Purpura Fulminans in a 20-Year-Old Female

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2021
A previously healthy 20-year-old female presented with extensive retiform purpura located at the face, upper and lower limbs, one week after an episode of acute tonsillitis.
Francisca Alves, Maria Manuel Brites, Inês Coutinho   +2 more
doaj   +1 more source

Genetic Variants in the Protein S (PROS1) Gene and Protein S Deficiency in a Danish Population

TH Open, 2021
Protein S (PS) deficiency is a risk factor for venous thromboembolism (VTE) and can be caused by variants of the gene encoding PS (PROS1). This study aimed to evaluate the clinical value of molecular analysis of the PROS1 gene in PS-deficient ...
Ole Halfdan Larsen, Alisa D. Kjaergaard, Anne-Mette Hvas, Peter H. Nissen   +3 more
doaj   +1 more source

Protein S Deficiency with Favourable Foetomaternal Outcome: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2023
Protein S is a multifunctional plasma protein, whose deficiency,results in a rare congenital thrombophilia, inherited in an autosomal dominant pattern.
Swati Sugandha, Shivanshi Sharma, Monika Jindal, Santosh Minhas   +3 more
doaj   +1 more source

A Difficult Case in Clinical Practice: Combined Polycythaemia Vera and Protein S Deficiency in a Patient with both Thrombotic and Bleeding Complications [PDF]

Journal of Clinical and Diagnostic Research, 2018
Polycythemia Vera (PV) is a chronic myeloproliferative disorder which is characterised by a high risk of developing arterial as well as venous thromboembolic complications like deep vein thrombosis, stroke, cortical vein thrombosis and rarely acute ...
Sushanth Wattal, Ashwal Adamane Jayaram, Padmakumar Ramachandran, Abdul UK Razak, Suheil Dhanse   +4 more
doaj   +1 more source

Inherited protein S deficiency due to a novel nonsense mutation in the PROS1 gene in the patient with recurrent vascular access thrombosis: A case report

Kidney Research and Clinical Practice, 2012
Vascular access thrombosis is one of the major causes of morbidity in patients maintained on chronic hemodialysis. Thrombophilia has been recognized as a risk factor of vascular access thrombosis.
Eun Jin Cho, Yong Chul Kim, Jin Ho Hwang, Hajung Lee, Sung Sup Park, So Yeon Kim, Suhnggwon Kim, Ho Jun Chin   +7 more
doaj   +1 more source

Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency

Haematologica, 2010
Background Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor.
Elisabetta Castoldi, Lisbeth F.A. Maurissen, Daniela Tormene, Luca Spiezia, Sabrina Gavasso, Claudia Radu, Tilman M. Hackeng, Jan Rosing, Paolo Simioni   +8 more
doaj   +1 more source

Deep Vein Thrombosis and Pulmonary Embolism Secondary to Thrombophilic Disorder: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Iron Deficiency Anaemia (IDA) is a prevalent nutritional deficiency and a common haematological disorder characterised by low iron levels, which lead to reduced haemoglobin production, fatigue, pallor and diminished oxygen delivery.
Satbir Kaur Malik, Vineetha Naga Lakshmi Giduturi, Sindhuri Goud Nimmala, Vijayashree Gokhale   +3 more
doaj   +1 more source

Intracranial Major Artery and Venous Sinus Thrombosis in a Young Male with MTHFR Mutation and Protein S Deficiency

Case Reports in Neurology, 2021
This case represents a unique example of stroke in a young patient involving major venous sinuses as well as major artery in a span of 6 months. After evaluation, he was found to have an abnormal thrombophilia profile.
Dhanashree Peddawad
doaj   +1 more source