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Protein C deficiency in a uremic patient: a rare case of multivessel thromboembolism and type 5 cardiorenal syndrome [PDF]

BMC Cardiovascular Disorders
Protein C deficiency is a rare inherited disorder characterized by low levels or impaired function of protein C, a natural anticoagulant protein. Deficiency in protein C activity leads to a hypercoagulable state, predominantly resulting in venous ...
Qisu Ying, Jie Shen, Xiu Yang, Yu Wu, Hongtao Wu, Xuexue Shi, Sai Wu, Ning Zhao, Ming Wang, Xin Li, Yong Mao   +10 more
doaj   +2 more sources

Comprehensive literature review of protein C concentrate use in patients with severe congenital protein C deficiency [PDF]

Research and Practice in Thrombosis and Haemostasis
Severe congenital protein C deficiency (SCPCD) is a rare disorder associated with life-threatening purpura fulminans and disseminated intravascular coagulation that typically present within hours after birth.
Csaba Siffel, Abhinav Wadhwa, Vanita Tongbram, Margaret Katana Ogongo, Henrik Sliwka, Hanna T. Gazda, Peter L. Turecek   +6 more
doaj   +2 more sources

Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan [PDF]

Thrombosis Journal
Background  We previously conducted a primary survey of pregnant women with hereditary thrombophilia based on national surveillance in Japan, but did not examine their thrombosis-related characteristics.
Takao Kobayashi, Kazuko Sugiura, Toshiyuki Ojima, Mariko Serizawa, Kyuya Hirai, Eriko Morishita   +5 more
doaj   +2 more sources

Successful Management of Neonatal Purpura Fulminans Caused by Congenital Protein C Deficiency: A Case Report [PDF]

Journal of Plastic and Reconstructive Surgery
Neonatal purpura fulminans, often caused by congenital protein C deficiency, presents with rapid onset of skin necrosis and microvascular thrombosis and can progress to disseminated intravascular coagulation.
Makiko Shiraishi, Naoto Yoshioka
doaj   +2 more sources

Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Dosing of intravenous protein C concentrate (Ceprotin) in patients with protein C deficiency is guided by pharmacokinetics (PK) of plasma protein C activity.
Zhaoyang Li, Inmaculada C. Sorribes, Jennifer Schneider, Adekemi Taylor   +3 more
doaj   +2 more sources

Surgical treatment of traction retinal detachment associated with compound heterozygous congenital protein C deficiency [PDF]

American Journal of Ophthalmology Case Reports, 2023
Purpose: Congenital protein C deficiency leads to a prothrombotic state that may result in potentially sight- and life-threatening thromboembolic attacks.
Tomoki Kurihara, Takao Endo, Shumpei Obata, Taeko Hotta, Naoki Nishio, Takayuki Iwaibara, Katsuya Hirata, Sakina Kuge, Yuhei Konishi, Daisuke Yoshida, Takahide Yanagi, Takashi Taga, Kazuko Wada, Norihisa Wada, Shouichi Ohga, Shunji Kusaka   +15 more
doaj   +2 more sources

Pharmacokinetic Evidence Supporting Subcutaneous Use of Protein C Concentrate in Patients with Protein C Deficiency [PDF]

TH Open
Zhaoyang Li, Inmaculada C. Sorribes, Jennifer Schneider, Adekemi Taylor   +3 more
doaj   +2 more sources

Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency

Biologics: Targets & Therapy, 2010
Sabine Kroiss, Manuela AlbisettiDivision of Hematology, University Children’s Hospital, Zurich, SwitzerlandAbstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation.
Sabine Kroiss, Manuela Albisetti
doaj   +2 more sources

Surfactant Protein C Deficiency in the Neonate. [PDF]

Dtsch Arztebl Int, 2022
Ehler J, Terpe F, Chao CM.
europepmc   +3 more sources

A quantitative assay system for protein C activity, the regulator of blood coagulation, based on a chromogenic method mimicking the blood coagulation cascade

Practical Laboratory Medicine, 2023
Background and aims: Protein C is a plasma protein, and its active form regulates blood coagulation. The recommended unit of protein C activity is IU/mL; however, some laboratories use percentage. Some deficiencies cannot be detected owing to measurement
Ryo Matsuda, Ruri Someya, Mutsumi Kobayashi, Eri Nakao, Momoka Hamasaki, Misuzu Shigeta, Hinako Hatae, Hiroyuki Kuma   +7 more
doaj   +1 more source