Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Dosing of intravenous protein C concentrate (Ceprotin) in patients with protein C deficiency is guided by pharmacokinetics (PK) of plasma protein C activity.
Zhaoyang Li +3 more
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Biologics: Targets & Therapy, 2008 Paul N KnoeblDepartment of Medicine 1, Division Hematology and Hemostasis, Medical University of Vienna, Vienna, AustriaAbstract: The protein C pathway has an important function in regulating and modulating blood coagulation and ensuring patency of the ...
Paul N Knoebl
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Comprehensive literature review of protein C concentrate use in patients with severe congenital protein C deficiency [PDF]
Research and Practice in Thrombosis and HaemostasisSevere congenital protein C deficiency (SCPCD) is a rare disorder associated with life-threatening purpura fulminans and disseminated intravascular coagulation that typically present within hours after birth.
Csaba Siffel +6 more
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Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan [PDF]
Thrombosis JournalBackground We previously conducted a primary survey of pregnant women with hereditary thrombophilia based on national surveillance in Japan, but did not examine their thrombosis-related characteristics.
Takao Kobayashi +5 more
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Use of human protein C concentrates in the treatment of patients with severe congenital protein C deficiency [PDF]
Biologics: Targets & Therapy, 2010 Sabine Kroiss, Manuela AlbisettiDivision of Hematology, University Children’s Hospital, Zurich, SwitzerlandAbstract: Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation.
Sabine Kroiss, Manuela Albisetti
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Protein C and S deficiency presenting as acute abdomen
Medical Journal of Dr. D.Y. Patil University, 2015 Protein C and S are essential in limiting the activation of coagulation in vivo. Their deficiencies predispose the patient to thrombophilia and leads to thrombosis, often at unusual sites. Arterial thrombosis is rarely observed.
Amit A Bharadiya +3 more
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Successful Management of Neonatal Purpura Fulminans Caused by Congenital Protein C Deficiency: A Case Report [PDF]
Journal of Plastic and Reconstructive SurgeryNeonatal purpura fulminans, often caused by congenital protein C deficiency, presents with rapid onset of skin necrosis and microvascular thrombosis and can progress to disseminated intravascular coagulation.
Makiko Shiraishi, Naoto Yoshioka
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Surgical treatment of traction retinal detachment associated with compound heterozygous congenital protein C deficiency [PDF]
American Journal of Ophthalmology Case Reports, 2023 Purpose: Congenital protein C deficiency leads to a prothrombotic state that may result in potentially sight- and life-threatening thromboembolic attacks.
Tomoki Kurihara +15 more
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Purpura fulminans due to acquired protein C deficiency
Indian Journal of Dermatology, 2015 Purpura fulminans (PF) may be the presenting symptom in a patient with protein C (PC) deficiency. It is a hematological emergency and presents with extensive areas of hemorrhagic necrosis of the skin.
Devdeep Mukherjee +2 more
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Pharmacokinetic Evidence Supporting Subcutaneous Use of Protein C Concentrate in Patients with Protein C Deficiency [PDF]
TH OpenZhaoyang Li +3 more
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