Results 321 to 330 of about 6,634,608 (387)

Characterizing Intermediate Conformations in Protein Conformational Space

2013
In this paper we present a novel parallel coordinate based clustering method using Gaussian mixture distribution models to characterize the conformational space of proteins. We detect highly populated regions which may correspond to intermediate states that are difficult to detect experimentally.
Rosanne Vetro, Nurit Haspel, Dan Simovici   +2 more
openaire   +1 more source

Conformational interconversion in protein crystals

Journal of Molecular Biology, 1992
We present evidence that the structure of carbonmonoxy myoglobin crystals can be altered by lowering the pH. This structural change is monitored by the characteristic Fe-CO Raman modes at 508 and 491 cm-1 and is thought to involve a localized distal pocket transition from a "closed" conformation at pH 7 to a more "open" conformation at pH 4.
L, Zhu, J T, Sage, A A, Rigos, D, Morikis, P M, Champion   +4 more
openaire   +2 more sources

Design of protein conformational switches

Current Opinion in Structural Biology, 2006
Protein conformational switches are ubiquitous in nature and often regulate key biological processes. To design new proteins that can switch conformation, protein designers have focused on the two key components of protein switches: the amino acid sequence must be compatible with the multiple target states and there must be a mechanism for perturbing ...
Xavier I, Ambroggio, Brian, Kuhlman
openaire   +2 more sources

Conformational Changes in Protein Function

2008
Conformational changes are the hallmarks of protein dynamics and are often intimately related to protein functions. Molecular dynamics (MD) simulation is a powerful tool to study the time-resolved properties of protein structure in atomic details.
Haiguang, Liu, Shubhra Ghosh, Dastidar, Hongxing, Lei, Wei, Zhang, Matthew C, Lee, Yong, Duan   +5 more
openaire   +2 more sources

Conformational mobility of immobilized proteins

Journal of Pharmaceutical and Biomedical Analysis, 2007
Cellular membrane fragments have been immobilized on the surface of a silica-based liquid chromatographic support and on the surface of glass capillaries to create immobilized receptor and drug transporter columns. These columns have included phases containing one subtype of the nicotinic receptor (alpha3beta2, alpha3beta4, alpha4beta2, alpha4beta4 ...
Ruin, Moaddel, Irving W, Wainer
openaire   +2 more sources

Protein conformation in bacterial spinae

Biopolymers, 1976
AbstractThe far uv circular dichroism (CD) and infrared spectra of bacterial spinae are reported. Estimates of the protein secondary structure were obtained by three‐component curve‐fitting methods supplemented by rank and factor analysis of CD data matrices. Native spinae were shown to contain approximately 88% antiparallel β‐sheet, 7% α‐helix, and 5%
R W, Coombs, J A, Verpoorte, K B, Easterbrook   +2 more
openaire   +2 more sources

Terahertz spectroscopy and machine learning algorithm for non-destructive evaluation of protein conformation

Optical and quantum electronics, 2020
Can Cao, Zhaohui Zhang, Xiaoyan Zhao, Tian-yao Zhang   +3 more
semanticscholar   +1 more source

Protein Conformational Dynamics

2014
1. Protein Folding Simulations by Generalized-ensemble Algorithms Takao Yoda, Yuji Sugita & Yuko Okamoto 2. Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules Lin-Tai Da, Fu Kit Sheong, Daniel-Adriano Silva & Xuhui Huang 3. Understanding Protein Dynamics Using Conformational Ensembles X.
openaire   +1 more source

Conformation of Proteins

Annual Review of Biochemistry, 1967
S N, Timasheff, M J, Gorbunoff
openaire   +2 more sources

Computed circular dichroism spectra for the evaluation of protein conformation.

Biochemistry, 1969
N. Greenfield, G. Fasman
semanticscholar   +1 more source