Results 121 to 130 of about 54,964 (292)

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Unravelling protein corona formation on pristine and leached microplastics

Microplastics and Nanoplastics
Upon entering the environment, the surface properties of pristine plastics are rapidly altered due to interactions with exogenous biomolecules, contaminants, and even microbiota, which ultimately alter their ecological impacts. When present in biological
Amanda Louise Dawson, Utpal Bose, Dongdong Ni, Joost Laurus Dinant Nelis   +3 more
doaj   +1 more source

Enhanced Competition at the Nano–Bio Interface Enables Comprehensive Characterization of Protein Corona Dynamics and Deep Coverage of Proteomes

, 2022
Shadi Ferdosi, Alexey Stukalov, Moaraj Hasan, Behzad Tangeysh, Tristan R. Brown, Tianyu Wang, Eltaher M. Elgierari, Xiaoyan Zhao, Yingxiang Huang, Amir Alavi, Brittany Lee‐McMullen, Jessica Chu, Mike Figa, Wei Tao, Jian Wang, Martin Goldberg, Evan S. O’Brien, Hongwei Xia, Craig Stolarczyk, Ralph Weissleder, Vivek F. Farias, Serafim Batzoglou, Asim Siddiqui, Omid C. Farokhzad, Daniel Hornburg   +24 more
openalex   +1 more source

Assessing the effect of protein corona formation in the process of EV surface engineering [PDF]

, 2023
Angelo Musicò, Rossella Zenatelli, Miriam Romano, Andrea Zendrini, Silvia Alacqua, Selene Tassoni, Lucia Paolini, Chiara Urbinati, Marco Rusnati, Paolo Bergese, Giuseppe Pomarico, Annalisa Radeghieri   +11 more
openalex   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona

Frontiers in Nanotechnology
Identifying the function and composition of the protein corona (i.e., the set of host proteins interacting with nanoparticles) is considered a crucial step in the development of nanoparticles for medical and pharmacological applications.
Maria Morbidelli, Emanuele Papini, Regina Tavano   +2 more
doaj   +1 more source

A different protein corona cloaks “true-to-life” nanoplastics with respect to synthetic polystyrene nanobeads

, 2022
Serena Ducoli, Stefania Federici, Roland Nicsanu, Andrea Zendrini, Claudio Marchesi, Lucia Paolini, Annalisa Radeghieri, Paolo Bergese, Laura E. Depero   +8 more
openalex   +2 more sources

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Protein corona and nanoparticles: how can we investigate on? [PDF]

, 2017
Francesca Pederzoli, Giovanni Tosi, Maria Angela Vandelli, Daniela Belletti, Flavio Forni, Barbara Ruozi   +5 more
openalex   +1 more source