Results 91 to 100 of about 103,093 (251)

Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer.
Abdelrahman Homedan, Darpan N. Pandya, Nicholas J. Schnicker, Thaddeus J. Wadas   +3 more
doaj   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Remote laboratory training for high school students: grocery store based hands-on project in protein crystallography. [PDF]

J Appl Crystallogr, 2023
Fox AL, Teteris AR, Mathews II.
europepmc   +1 more source

Exploring serial crystallography for drug discovery

IUCrJ
Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug
A. Dunge, C. Phan, O. Uwangue, M. Bjelcic, J. Gunnarsson, G. Wehlander, H. Käck, G. Brändén   +7 more
doaj   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Understanding Cysteine Chemistry Using Conventional and Serial X-Ray Protein Crystallography. [PDF]

Crystals (Basel), 2022
Smith N, Wilson MA.
europepmc   +1 more source

Synthesis and Biological Profile of Substituted Pyrrolidinyl Carboxamides for Acyl‐ACP Thioesterase Inhibition

European Journal of Organic Chemistry, EarlyView.
The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus, Martin Annau, Neanne Alnafta, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Ralf Braun, Ronald W. Brown, Luke R. Churchman, Christine Dörnbrack, Andrew Earl, Tyler Fahrenhorst‐Jones, Jörg Freigang, Claudia Hartfiel, Ines Heinemann, Arnim Köhn, Bernd Laber, Michael C. McLeod, Catherine S. Meister, Gudrun Lange, Luka Posa, Shaun Rees, Dirk Schmutzler, Anna M. Reingruber, Jens Frackenpohl   +24 more
wiley   +1 more source

Unlocking the Potential of Carbon Nitride (CxNy) Electrocatalysts in Hydrogen Evolution, Oxygen Evolution and Overall Water Splitting

Exploration, EarlyView.
Electrocatalytic water splitting with carbon nitride (CxNy) materials has gained attention due to their synthesis, structure, and robust application. Among various CxNy types, g‐C3N4 is the most stable allotrope and extensively researched. This review explores recent advances in HER, OER, and OWS, focusing on defect engineering, structural engineering,
Zi Wei Tan, Neil Felicio Agesta, Ryan Yow Zhong Yeo, Joel Jie Foo, Wee‐Jun Ong   +4 more
wiley   +1 more source

Implementation of wedged-serial protein crystallography at PROXIMA-1. [PDF]

J Synchrotron Radiat, 2022
Chaussavoine I, Isabet T, Lener R, Montaville P, Vasireddi R, Chavas LMG.   +5 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source