Results 101 to 110 of about 4,121,048 (281)
Advanced Science, EarlyView.Bicyclo[1.1.0]butanes undergo a Lewis acid‐catalyzed formal (3 + 3) annulation with indolyl alcohols to furnish indole‐fused aza‐bicyclo[3.1.1]heptanes. Strain‐release‐driven C‐C bond formation, followed by C‐N bond formation via ring expansion, enables the rapid assembly of rigid, sp3‐rich bicyclic architectures under mild reaction conditions ...
Mainak Dey +4 more
wiley +1 more source
Switching ATP‐Forming Phosphoryl‐Transfer Chemistry With a Restricted Set of Amino Acids
Angewandte Chemie, EarlyView.Constraints on amino acid composition relevant to prebiotic chemistry reshape enzyme chemistry by replacing the canonical mechanism within a conserved protein fold with a distinct ATP‐forming reaction, ADP disproportionation. Such constraints generate alternative catalytic solutions not observed in modern enzymes and point to chemically plausible early
Sota Yagi +3 more
wiley +2 more sources
Unusual traits shape the architecture of the Ig ancestor molecule
Communications BiologyUnderstanding the ancestral Ig domain’s molecular structure and tracing the evolution of Ig-like proteins are fundamental components missing from our comprehension of their evolutionary trajectory and function.
Alejandro Urdiciain +6 more
doaj +1 more source
Two-dimensional pixel array image sensor for protein crystallography [PDF]
, 1996 A 2D pixel array image sensor module has been designed for time resolved Protein Crystallography. This smart pixels detector significantly enhances time resolved Laue Protein crystallography by two to three orders of magnitude compared to existing ...
Beuville, E., Beche, J.-F., Cork, C.
core +1 more source
Crystal Structure Prediction of Inorganic Materials: A Benchmark and Modern Evaluation
Advanced Intelligent Discovery, EarlyView.Predicting a crystal’s structure from composition alone is a long‐standing challenge in materials discovery. The CSP180 benchmark of 180 inorganic crystals evaluates thirteen crystal structure prediction algorithms requiring no density functional theory (DFT) against DFT‐based baselines across twelve metrics.
Lai Wei +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A photoswitchable ligand was used to trigger conformational changes within the thrombin binding aptamer DNA G‐Quadruplex. These reversible ligand driven rearrangements were examined by time‐resolved NMR experiments to gain insight of the dynamic folding landscape of the G‐quadruplex.
Jason Martins +2 more
wiley +2 more sources
Microfluidics-Based Strategies for Protein Crystallography [PDF]
, 2009 Protein crystallography is an invaluable tool for the study of biological processes at the molecular level. While several crystallization techniques are actively pursued in both academic and industrial laboratories to produce high-quality protein ...
Megan J. Anderson, Anderson, Megan Jo
core +1 more source
In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores
Angewandte Chemie, EarlyView.The generation of neoproteins—functional proteins containing unnatural amino acids—is a key goal in synthetic biology. We develop a platform to discover neoproteins with specified bioactivity from trillion‐member sequence libraries, using genetic code reprogramming, in vitro selection and microwave peptide synthesis.
Adam Beattie +5 more
wiley +2 more sources
Deciphering the initiation pathway of CagT4SS assembly by in vitro reconstitution of subcomplexes
Nature CommunicationsCag type IV secretion system (CagT4SS) mediates the translocation of diverse substrates and is critical for the Helicobacter pylori pathogenesis. Its assembly is initiated by the central cylinder comprising CagX, CagY and CagM, however, the order and ...
Hoi Yee Chu +5 more
doaj +1 more source
Biocrystallography in Switzerland: Achievements and Future Perspectives
CHIMIA, 2014 The first protein crystallography group in Switzerland was installed at the Biozentrum of the University of Basel approximately 40 years ago.
Markus G. Grütter
doaj +1 more source