Results 121 to 130 of about 4,121,048 (281)

Direct protein crystallization on ultrathin membranes for diffraction measurements at X-ray free-electron lasers [PDF]

, 2017
A new era of protein crystallography started when X-ray free-electron lasers (XFELs) came into operation, as these provide an intense source of X-rays that facilitates data collection in the 'iffract-before-destroy' regime.
Stahlberg, Henning, Padeste, Celestino, Braun, Thomas, Martiel, Isabelle, Opara, Nadia, Arnold, Stefan A., David, Christian, Makita, Mikako, Celestino Padeste, Nadia Opara, Opara, Nadia (author), Stahlberg, Henning (author), Mikako Makita, David, Christian (author), Thomas Braun, Arnold, Stefan A. (author), Padeste, Celestino (author), Isabelle Martiel, Christian David, Makita, Mikako (author), Henning Stahlberg, Martiel, Isabelle (author), Stefan A. Arnold, Braun, Thomas (author)   +23 more
core   +1 more source

Structures of Helicobacter pylori C-terminal protease CtpA reveal a new mode of self-contained proteolytic processing

Communications Biology
Bacterial carboxyl-terminal processing proteases (CTPs) are essential for protein quality control, signal transduction, and cell adaptation. Typically, activation of CTPs involves substrate binding to the PDZ domain or an adaptor protein.
Kailei Sun, Lili Yan, Chin Yu Mok, Pui Kin So, Sirius Pui Kam Tse, Kwok Fai Lau, Daping Wang, Huawei Zhang, Shannon Wing Ngor Au   +8 more
doaj   +1 more source

Protein crystallography and fragment-based drug design

, 2013
Crystallography is a major tool for structure-driven drug design, as it allows knowledge of the 3D structure of protein targets and protein–ligand complexes.
Belviso DB, Aresta BM, Caliandro R, DE CANDIA, MODESTO, ALTOMARE, Cosimo Damiano, Aresta Brunella Maria, de Candia Modesto, Belviso Danilo Benny, Altomare Cosimo Damiano, Caliandro Rocco   +9 more
core   +1 more source

The time revolution in macromolecular crystallography

Structural Dynamics
Macromolecular crystallography has historically provided the atomic structures of proteins fundamental to cellular functions. However, the advent of cryo-electron microscopy for structure determination of large and increasingly smaller and flexible ...
Georgii Khusainov, Joerg Standfuss, Tobias Weinert   +2 more
doaj   +1 more source

Development of a humanized anti-FABP4 monoclonal antibody for potential treatment of breast cancer

Breast Cancer Research
Background Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular mechanisms.
Jiaqing Hao, Rong Jin, Yanmei Yi, Xingshan Jiang, Jianyu Yu, Zhen Xu, Nicholas J. Schnicker, Michael S. Chimenti, Sonia L. Sugg, Bing Li   +9 more
doaj   +1 more source

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Nature Communications, 2017
mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in ...
Ryo Yonehara, Shigeyuki Nada, Tomokazu Nakai, Masahiro Nakai, Ayaka Kitamura, Akira Ogawa, Hirokazu Nakatsumi, Keiichi I. Nakayama, Songling Li, Daron M. Standley, Eiki Yamashita, Atsushi Nakagawa, Masato Okada   +12 more
doaj   +1 more source

Using structural genomics depositions in undergraduate teaching of protein crystallography: everybody wins. [PDF]

Acta Crystallogr F Struct Biol Commun, 2023
Agirre J.
europepmc   +1 more source

High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography. [PDF]

J Vis Exp, 2023
Budziszewski GR, Snell ME, Wright TR, Lynch ML, Bowman SEJ.   +4 more
europepmc   +1 more source

Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer.
Abdelrahman Homedan, Darpan N. Pandya, Nicholas J. Schnicker, Thaddeus J. Wadas   +3 more
doaj   +1 more source

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography. [PDF]

J Appl Crystallogr, 2023
Vakili M, Han H, Schmidt C, Wrona A, Kloos M, de Diego I, Dörner K, Geng T, Kim C, Koua FHM, Melo DVM, Rappas M, Round A, Round E, Sikorski M, Valerio J, Zhou T, Lorenzen K, Schulz J.   +18 more
europepmc   +1 more source