Results 91 to 100 of about 4,121,048 (281)

Protein X-ray Crystallography and Drug Discovery

Molecules, 2020
With the advent of structural biology in the drug discovery process, medicinal chemists gained the opportunity to use detailed structural information in order to progress screening hits into leads or drug candidates.
Laurent Maveyraud, Lionel Mourey
doaj   +1 more source

4.1 - Protein Crystallography

, 2016
Review of crystallography. Role of crystallography in modern biology. Outline of steps and process in protein crystallography as an important special case of single-crystal crystallography.
Heiney, Paul A.
core  

The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis [PDF]

, 2012
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide ...
Summers, Emma Louise
core  

Journal of Applied Crystallography: the first 50 years and beyond

, 2018
The Editors of Journal of Applied Crystallography mark the journal's 50th anniversary.
Andrew J. Allen, Allen, Andrew J.,, Janos Hajdu, McIntyre, Garry J.,, Hajdu, Janos,, Garry J. McIntyre   +5 more
core   +1 more source

PrOMet: Accurate and Robust Metal‐Binding Site and Type Prediction

Advanced Science, EarlyView.
PrOMet is a two‐stage deep learning framework for jointly predicting metal‐binding sites and ion identities from protein structures. Surface candidate sites are first pruned, followed by refinement of the most probable sites and metal types. This hierarchical strategy enables robust and accurate metal prediction for cryo‐EM and AlphaFold‐derived ...
Gangeun Park, Chaok Seok, Hahnbeom Park
wiley   +1 more source

Extending Small‐Molecule Aptamer Discovery Principles to Protein Targets: Selection and Characterization of Green Fluorescent Protein Aptamers

Angewandte Chemie, EarlyView.
Protein‐binding aptamers remain poorly understood compared to their small‐molecule counterparts. Using green fluorescent protein (GFP) variants as a tractable model system, we show how subtle changes in protein surface composition and divalent metal ions reshape aptamer selection, specificity, and binding.
Stefen Stangherlin, Nathan Wong, Logan Fanning, Kate Kim, Peter Kim, Iffat Tabassum, Songyang Miao, Rui Huang, Juewen Liu   +8 more
wiley   +2 more sources

STARS: Spread the beauty of DNA Crystallography [PDF]

Structural Dynamics
Very few freshmen at Georgia Tech have heard about DNA or Protein crystallography, not to mention its importance in structural advancement of protein functions, or let alone its beauty in nature.
Chenyi Andrew, Susanna Huang
doaj   +1 more source

Protein engineering as a tool for crystallography

Current Opinion in Biotechnology, 1995
The generation of large quantities of protein by overexpression technology has enabled structural studies of many important molecules that are found in only minute quantities in the cell. An increasing number of structures of proteins overexpressed in non-native systems have been solved.
Price, SR, Nagai, K
openaire   +3 more sources

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

The crystal structure of Acinetobacter baumannii bacterioferritin reveals a heteropolymer of bacterioferritin and ferritin subunits

Scientific Reports
Iron storage proteins, e.g., vertebrate ferritin, and the ferritin-like bacterioferritin (Bfr) and bacterial ferritin (Ftn), are spherical, hollow proteins that catalyze the oxidation of Fe2+ at binuclear iron ferroxidase centers (FOC) and store the Fe3+
Huili Yao, Suliat Alli, Lijun Liu, Anabel Soldano, Anne Cooper, Leo Fontenot, Dristen Verdin, Kevin P. Battaile, Scott Lovell, Mario Rivera   +9 more
doaj   +1 more source