Results 151 to 160 of about 4,121,048 (281)
A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells
Chemistry – A European Journal, EarlyView.A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak +9 more
wiley +1 more source
Structure and Dynamics of Porin Loops in Asymmetric Outer Membranes of E. coli
Chemistry – A European Journal, EarlyView.What are loops of membrane proteins doing within the oligosaccharide coat of cells? This structurally unexplored space is studied by solid‐state NMR, with the outer membrane protein G (OmpG) embedded in asymmetric E. coli outer membrane (OM) vesicles as a paradigmatic example.
Morgane Adélaïde +13 more
wiley +1 more source
Trends and Future Directions in Organic Chemistry for Drug Discovery
Chemistry – A European Journal, EarlyView.Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley +1 more source
C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screening. [PDF]
Acta Crystallogr D Struct Biol, 2021 Sarrou I +5 more
europepmc +1 more source
Getting the Big Ones to Pack: Crystal Structure of Vitamin K2 With a Chaperone
Chemistry – A European Journal, EarlyView.A method for obtaining co‐crystals of medium‐size organic molecules and ‐tetrakis(2‐fluoro‐4‐methoxyphenyl)adamantane (TFM) as chaperone was developed. This method yielded a high‐resolution x‐ray crystal structure of menaquinone MK‐4 (vitamin K2), in which layers of chaperone and vitamin guest molecules are found.
Jan Hartenfels +5 more
wiley +1 more source
Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein. An X-ray Crystallography Study
, 2004 Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein.
BOVI, Michele +5 more
core +1 more source
ChemSusChem, Volume 18, Issue 6, March 15, 2025.Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova +8 more
wiley +1 more source
Generative Models in Inorganic Crystals Discovery and Inverse Design
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Generative inverse‐design samples from the vast inorganic crystal design space by starting from target properties such as band gap, stability, and ion transport. This Review examines the representations, generative models, and validation workflows needed to translate candidate structures into stable, potentially synthesizable materials for applications
Tao Li +5 more
wiley +1 more source