Results 171 to 180 of about 4,121,048 (281)

Protein Crystallography

Journal of Pesticide Science, 2003
openaire   +3 more sources

50th anniversary of the Stanford SSRL synchrotron radiation and protein crystallography initiative. [PDF]

J Synchrotron Radiat
Helliwell JR, Nave C, Szebenyi DM.
europepmc   +1 more source

Structural and Stability Analysis of de Novo Designed Proteins Incorporating a Plant Self‐Incompatibility Motif

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi, Koya Sakuma, Yoshitaka Moriwaki, Naoki Aoyama, Toma Kashima, Tohru Terada, Akimasa Miyanaga, Shinya Fushinobu   +7 more
wiley   +1 more source

Genetic Algorithm-Enhanced Direct Method in Protein Crystallography. [PDF]

Molecules
Fu R, Su WP, He H.
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

High-throughput protein crystallography to empower natural product-based drug discovery. [PDF]

Acta Crystallogr F Struct Biol Commun
Meneghello R, Rustiguel JK, de Araújo EA, de Felício R, Fernandes AZN, Ferreira ELF, Gubiani JR, Takeda AAS, Araujo A, de Lima Silva CC, Bertonha AF, Urano RPM, Trindade DM, Cunha TM, Cardoso AC, Berlinck RGS, Nascimento AFZ, Trivella DBB.   +17 more
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Spatial Gene Expression in Fungi: mRNA Localization, Condensates, and Beyond

Yeast, EarlyView.
ABSTRACT Polarized growth and cellular asymmetry are broadly conserved properties of fungal life, from transient bud‐site selection in unicellular yeasts to sustained hyphal extension in filamentous and coenocytic species. While vesicle trafficking, cytoskeletal organization, and cell‐wall remodeling are well‐established contributors to these processes,
Sander van Otterdijk, Zixu Wang, Roan Arends, Evelina Tutucci   +3 more
wiley   +1 more source

Protein Crystallography

Journal of Pesticide Science, 2004
openaire   +3 more sources

On-the-fly resolution enhancement in X-ray protein crystallography using electric field. [PDF]

Eur Biophys J
Khakurel KP, Nemergut M, Pant P, Savko M, Andreasson J, Žoldák G.   +5 more
europepmc   +1 more source